Zhang Danying, Wang Xin, Sun Xiaoqiang, Fang Shulin, Xiong Ge, Cheng Chang, Gu Meiling, Yao Shuqiao, Dong Daifeng, Wang Xiang
Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, China.
Depress Anxiety. 2024 Oct 16;2024:5526584. doi: 10.1155/2024/5526584. eCollection 2024.
High psychological resilience (HR) could protect individuals from psychosocial stress and thereby make individuals less vulnerable to depression and anxiety; however, the underlying neural mechanism remains to be investigated. The Montreal Imaging Stress Task (MIST) was administered to participants of 59 healthy individuals with HR and 56 individuals with low psychological resilience (LR) during functional magnetic resonance imaging (fMRI) scanning. Cortisol concentrations and subjective stress levels were collected across the MIST. Repeated measures analyses of variance were conducted to measure the group differences in subjective and cortisol stress responses. Two-sample -tests were conducted to detect the group differences in stress-related brain activation and functional connectivity (FC). The LR group exhibited an increase in cortisol concentration after the MIST, whereas the HR group exhibited a decrease in cortisol concentration after the MIST. The LR group exhibited higher activation in the left anterior insula and lower FC between the left orbitofrontal cortex (OFC) and the right temporal pole (TP) (all < 0.05). Mediation analyses revealed that the left anterior insula mediates the relationship between psychological resilience and depression and the left OFC-right TP FC mediates the relationship between psychological resilience and anxiety. Findings highlight that the anterior insula and OFC-TP FC could be the critical neural mechanism underlying the interaction between psychological resilience and psychosocial stress. Moreover, higher anterior insula activation and lower OFC-TP FC could be the crucial neural mechanism of individuals with low psychological resilience developing into depression/anxiety when experiencing daily psychosocial stressors.
高心理复原力（HR）可以保护个体免受心理社会压力的影响，从而使个体更不容易患抑郁症和焦虑症；然而，其潜在的神经机制仍有待研究。在功能磁共振成像（fMRI）扫描过程中，对59名具有高心理复原力的健康个体和56名低心理复原力（LR）个体进行了蒙特利尔成像应激任务（MIST）测试。在整个MIST过程中收集了皮质醇浓度和主观压力水平。进行重复测量方差分析以测量主观和皮质醇应激反应的组间差异。进行双样本t检验以检测与应激相关的大脑激活和功能连接（FC）的组间差异。LR组在MIST后皮质醇浓度升高，而HR组在MIST后皮质醇浓度降低。LR组在左侧前脑岛表现出更高的激活，并且在左侧眶额皮质（OFC）和右侧颞极（TP）之间表现出更低的FC（所有p < 0.05）。中介分析表明，左侧前脑岛介导心理复原力与抑郁之间的关系，左侧OFC-右侧TP FC介导心理复原力与焦虑之间的关系。研究结果突出表明，前脑岛和OFC-TP FC可能是心理复原力与心理社会压力之间相互作用的关键神经机制。此外，较高的前脑岛激活和较低的OFC-TP FC可能是低心理复原力个体在经历日常心理社会压力源时发展为抑郁/焦虑的关键神经机制。
