Gerdin E, Tydén O, Eriksson U J
Pediatr Res. 1985 Jul;19(7):687-91. doi: 10.1203/00006450-198507000-00010.
This report describes the development of superoxide dismutase, glutathione peroxidase, and catalase activities in fetal (days 16-22) and neonatal (day 2 postpartum) lungs of normal rats. Each of the enzymes showed an individual pattern of development in the perinatal period. Glutathione peroxidase activity increased by 135% (p less than 0.001) during the last 3 days before birth, catalase activity by 105% (p less than 0.01) during the first 2 postnatal days, and the activity of superoxide dismutase by 52% (p less than 0.05) from gestational day 19 to 2 days after birth. Contamination by superoxide dismutase from blood in the lung samples accounted for less than 2% of the activity. In contrast, not less than 10-30% of glutathione peroxidase and catalase originated from the blood; and corrections were made for this source of error in each sample.
本报告描述了正常大鼠胎儿（第16 - 22天）和新生大鼠（出生后第2天）肺中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性的发育情况。每种酶在围产期都呈现出独特的发育模式。出生前最后3天，谷胱甘肽过氧化物酶活性增加了135%（p < 0.001）；出生后前2天，过氧化氢酶活性增加了105%（p < 0.01）；从妊娠第19天到出生后2天，超氧化物歧化酶活性增加了52%（p < 0.05）。肺样本中来自血液的超氧化物歧化酶污染占活性的比例不到2%。相比之下，谷胱甘肽过氧化物酶和过氧化氢酶至少有10 - 30%来自血液；并对每个样本的这一误差来源进行了校正。
