Yeo Seung Geun, Oh Yeon Ju, Lee Jae Min, Kim Sung Soo, Park Dong Choon
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of Korea.
Department of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Antioxidants (Basel). 2025 Feb 20;14(3):247. doi: 10.3390/antiox14030247.
Nitric oxide (NO) is a key signaling molecule involved in cellular communication and plays a critical role in various biological processes. Given its dual role in the pathogenesis of endometriosis, we conducted a systematic literature review to explore its mechanisms further. Numerous studies have investigated the expression and role of NO in various diseases, including those in the field of gynecology. However, the expression and role of NO in endometriosis remain a topic of ongoing debate. Therefore, we conducted a comprehensive literature review using the Cochrane Library, EMBASE, Google Scholar, PubMed, and SCOPUS databases to evaluate the induction and role of NO in the pathogenesis of endometriosis. Of the 27 papers ultimately reviewed, 22 (81.4%) reported that NO contributes to the pathogenesis of endometriosis, 3 (11.1%) suggested that NO acts as a protective mechanism against endometriosis, and 2 studies (7.4%) found no association between NO and the pathogenesis of endometriosis. The expression and levels of NO in endometriosis were associated with pregnancy, infertility, menstruation, and pelvic pain. Research conducted on rats and mice demonstrated that NO, nNOS, eNOS, and iNOS play significant roles in the development of endometriosis. Most studies suggested that increased NO levels are associated with the pathogenesis of endometriosis.
一氧化氮（NO）是参与细胞通讯的关键信号分子，在各种生物学过程中起关键作用。鉴于其在子宫内膜异位症发病机制中的双重作用，我们进行了系统的文献综述以进一步探索其机制。众多研究已调查了NO在包括妇科领域在内的各种疾病中的表达和作用。然而，NO在子宫内膜异位症中的表达和作用仍是一个持续争论的话题。因此，我们使用考克兰图书馆、EMBASE、谷歌学术、PubMed和SCOPUS数据库进行了全面的文献综述，以评估NO在子宫内膜异位症发病机制中的诱导作用和作用。在最终审查的27篇论文中，22篇（81.4%）报告称NO促成子宫内膜异位症的发病机制，3篇（11.1%）表明NO作为对抗子宫内膜异位症的保护机制，2项研究（7.4%）发现NO与子宫内膜异位症的发病机制之间无关联。子宫内膜异位症中NO的表达和水平与妊娠、不孕、月经和盆腔疼痛有关。对大鼠和小鼠进行的研究表明，NO、nNOS、eNOS和iNOS在子宫内膜异位症的发展中起重要作用。大多数研究表明，NO水平升高与子宫内膜异位症的发病机制有关。
