Olig R M, Staton R D, Beatty W W, Wilson H, Biberdorf R I, Hoag S G, Brumback R A
Percept Mot Skills. 1985 Jun;60(3):879-89. doi: 10.2466/pms.1985.60.3.879.
Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.
对20名正在接受重度抑郁症治疗的儿童进行了检测，测量了他们在达到2.25毫克/千克体重的药物剂量后2周以及5至10周时血浆中丙咪嗪、阿米替林及其去甲基代谢物的浓度。在2周时，所有儿童均表现出临床症状改善，但到10周时，接受丙咪嗪治疗的10名儿童中有4名以及接受阿米替林治疗的10名儿童中有5名出现了抑郁症状的临床复发。在保持临床症状改善的儿童亚组和复发的儿童亚组中，三环类抗抑郁药的血浆浓度及比值相当。在复发的儿童中，没有证据表明血浆三环类抗抑郁药浓度出现系统性下降。
