Siedlecka-Kroplewska Kamila, Kmiec Zbigniew, Zmijewski Michal Aleksander
Department of Histology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Department of Anatomy and Histology, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Antioxidants (Basel). 2025 Mar 13;14(3):339. doi: 10.3390/antiox14030339.
Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They are phytoalexins produced in diverse plant species in response to stress, such as fungal and bacterial infections or excessive UV irradiation. Plant-derived dietary products containing stilbenes are common components of the human diet. Stilbenes appear to be promising chemopreventive and chemotherapeutic agents. Accumulating evidence indicates that stilbenes are able to trigger both apoptotic and autophagic molecular pathways in many human cancer cell lines. Of note, the molecular crosstalk between autophagy and apoptosis under cellular stress conditions determines the cell fate. The autophagy and apoptosis relationship is complex and depends on the cellular context, e.g., cell type and cellular stress level. Apoptosis is a type of regulated cell death, whereas autophagy may act as a pro-survival or pro-death mechanism depending on the context. The interplay between autophagy and apoptosis may have an important impact on chemotherapy efficiency. This review focuses on the in vitro effects of stilbenes in different human cancer cell lines concerning the interplay between autophagy and apoptosis.
植物源芪类化合物是低分子量多酚类化合物，具有抗氧化、抗微生物、抗真菌、抗炎、抗糖尿病、心脏保护、神经保护和抗癌活性。它们是多种植物物种在受到应激（如真菌和细菌感染或过度紫外线照射）时产生的植保素。含芪类化合物的植物性膳食产品是人类饮食的常见组成部分。芪类化合物似乎是很有前景的化学预防和化疗药物。越来越多的证据表明，芪类化合物能够在许多人类癌细胞系中触发凋亡和自噬分子途径。值得注意的是，细胞应激条件下自噬与凋亡之间的分子串扰决定了细胞命运。自噬与凋亡的关系很复杂，取决于细胞环境，如细胞类型和细胞应激水平。凋亡是一种程序性细胞死亡，而自噬根据具体情况可能作为一种促生存或促死亡机制。自噬与凋亡之间的相互作用可能对化疗效果产生重要影响。本综述重点关注芪类化合物在不同人类癌细胞系中关于自噬与凋亡相互作用的体外效应。
