Gao Xiuming, Yang Na, Sang Miaomiao, Shang Xiaona, Feng Tao, Zhou Jie, Zhang Yi
The Third Affiliated Hospital of Soochow University, Changzhou, 213004, Jiangsu, China.
Department of Rehabilitation Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Neurol Sci. 2025 Apr 14. doi: 10.1007/s10072-025-08132-8.
Prosopometamorphopsia (PM) is a high-level visual-perceptual disorder characterized by facial distortion. Unilateral PM caused by splenium lesions in the corpus callosum (CC) is rare.
To investigate the role of CC splenium lesions in unilateral PM and explore their implications for facial information processing and rehabilitation.
We reported four cases of PM due to splenium lesions in the CC and conducted a retrospective analysis of 17 previously reported cases. A comprehensive evaluation framework was developed to assess primary, intermediate, and advanced visual processing in PM patients. Additionally, individualized rehabilitation strategies incorporating avoidance and compensatory methods were implemented.
CC splenium lesions were identified as the most common cause of unilateral PM, with a tendency toward bottom-up processing. Disconnection syndromes associated with CC splenium lesions were also observed. Patients showed a relatively favorable recovery rate, suggesting dynamic compensatory mechanisms in bilateral facial processing, with stronger compensatory functions in the right hemisphere.
The splenium of the corpus callosum plays a crucial role in bilateral facial information processing, exerting a lateralized influence on the right hemisphere. Further studies are needed to confirm these findings and elucidate the underlying pathophysiological mechanisms.
面孔变形视幻觉（PM）是一种以面部扭曲为特征的高级视觉感知障碍。胼胝体压部（CC）病变引起的单侧PM较为罕见。
探讨CC压部病变在单侧PM中的作用，并探讨其对面部信息处理和康复的意义。
我们报告了4例因CC压部病变导致的PM病例，并对之前报告的17例病例进行了回顾性分析。制定了一个综合评估框架，以评估PM患者的初级、中级和高级视觉处理。此外，还实施了包括回避和补偿方法的个性化康复策略。
CC压部病变被确定为单侧PM的最常见原因，具有自下而上处理的倾向。还观察到与CC压部病变相关的分离综合征。患者显示出相对良好的恢复率，表明双侧面部处理中存在动态补偿机制，右半球的补偿功能更强。
胼胝体压部在双侧面部信息处理中起关键作用，对右半球产生偏侧化影响。需要进一步研究来证实这些发现并阐明潜在的病理生理机制。
