Venous Resection During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma-A Multicentre Propensity Score Matching Analysis of the Recurrence After Whipple's (RAW) Study.

: Pancreatoduodenectomy with venous resection (PDVR) may be performed to achieve tumour clearance in patients with a pancreatic ductal adenocarcinoma (PDAC) with venous involvement. This study aimed to evaluate the impact of PDVR on PDAC outcomes. : In total, 435 PDAC patients with either R0 status ( = 322) or R1 status within the superior mesenteric vein groove ( = 113) were extracted from the Recurrence After Whipple's (RAW) study dataset. PDVR patients were matched in a 1:2 ratio with standard PD patients. Comparisons were then made between the two groups (surgical radicality and survival). : A total of 81 PDVRs were matched with 162 PDs. Neoadjuvant chemotherapy (5.7% vs. 13.6%, = 0.032) and R1 resection rates (17.9% vs. 42%, < 0.001) were higher in the PDVR group. Risk factors for R1 resection included venous resection ( < 0.001 for sleeve and = 0.034 for segmental resection), pT3 ( = 0.007), and pN1 stage ( = 0.045). PDVR patients had lower median overall survival (OS, 21 vs. 30 months (m), = 0.023) and disease-free survival (DFS, 17 m vs. 24 m, = 0.043). Among PDVR patients, R status did not impact on OS (R0: 23 m, R1: 21 m, = 0.928) or DFS (R0: 18 m, R1: 17 m, = 0.558). Irrespective of R status, systemic recurrence was higher in the PDVR group ( = 0.034). : Independent of R status, the PDVR group had lower overall survival and higher systemic recurrence rates.