Kutzner J, Eckmann A, Grimm W
Nuklearmedizin. 1985 Apr;24(2):87-9.
Therapeutic doses of 90Y-citrate show a high selective accumulation in bone. Bone marrow is the critical organ. Investigations in rats show a decrease of leucocytes, erythrocytes and thrombocytes depending on dose. A significant decrease of the leucocytes and thrombocytes was seen with 0.5 mCi (17.5 MBq) 90Y per kg bodyweight, with 2.0 mCi (74 MBq) also of the erythrocytes. This would be equivalent to a dose of 35 to 140 mCi (1.295 to 5.18 GBq) for a normal patient (70 kg). Therefore, a single dose of 10 mCi (370 MBq) of 90Y-citrate should be tolerated by a tumor patient without any blood cell depression, if there was no prior chemotherapy.
治疗剂量的90Y-柠檬酸盐在骨骼中显示出高度选择性聚集。骨髓是关键器官。对大鼠的研究表明，白细胞、红细胞和血小板数量会随剂量减少。当每千克体重给予0.5毫居里（17.5兆贝可）的90Y时，白细胞和血小板显著减少；给予2.0毫居里（74兆贝可）时，红细胞也显著减少。这相当于一名体重70千克的正常患者接受35至140毫居里（1.295至5.18吉贝可）的剂量。因此，如果没有先前的化疗，肿瘤患者单次给予10毫居里（370兆贝可）的90Y-柠檬酸盐应该能够耐受，而不会出现任何血细胞减少。
