Kutzner J, Alfter G, Grimm W
Nuklearmedizin. 1986 Apr;25(2):78-80.
There is little change in the organ distribution of yttrium citrate complex after addition of 0.01 mg/kg BW as carrier. Adding increasing amounts of inactive yttrium up to 1 mg/kg BW caused a considerable reduction in bone uptake and an increasing accumulation in the liver and spleen by transformation to colloid. Uptake in the lung indicates formation of macro-particles. The transformation into colloid can be varied by changing the citrate concentration. The 90Y-citrate complex for therapy should be used either without or with very little carrier of inactive yttrium.
添加0.01mg/kg体重的载体后，柠檬酸钇络合物的器官分布几乎没有变化。添加高达1mg/kg体重的非活性钇，会导致骨摄取显著降低，并通过转化为胶体而在肝脏和脾脏中积累增加。肺中的摄取表明形成了大颗粒。通过改变柠檬酸盐浓度可以改变向胶体的转化。用于治疗的90Y-柠檬酸盐络合物应在无或含有极少非活性钇载体的情况下使用。
