阻塞性睡眠呼吸暂停与帕金森病的关系：系统评价和荟萃分析。

The relationship between obstructive sleep apnea and Parkinson's disease: a systematic review and meta-analysis.

机构信息

Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

出版信息

Neurol Sci. 2020 May;41(5):1153-1162. doi: 10.1007/s10072-019-04211-9. Epub 2020 Jan 2.

DOI:10.1007/s10072-019-04211-9

PMID:31897944

Abstract

BACKGROUND

Obstructive sleep apnea (OSA) is a common sleep disorder in Parkinson's disease (PD). However, the relationship between OSA and PD is still inconsistent. Our study was aimed to evaluate the relationship between PD and OSA.

METHODS

Studies on OSA and PD were searched using PubMed, Embase, Web of Science, Cochrane library, and Chinese National Knowledge Infrastructure databases. Review Manager 5.3 software was used to calculate the pooled estimate effect. The inverse variance model was used to pool the mean difference (MD) or hazard ratios (HRs); the Mantel-Haenszel method was used to pool the odds ratio (OR). Heterogeneity among the studies was assessed using I statistic and Q test.

RESULTS

A total of 12 studies with 93,332 cases were deemed eligible and included in our meta-analysis. Overall, the occurrence of PD was more frequent in patients with OSA (HR 1.59, 95% CI, 1.36-1.85). The subgroup analysis demonstrated the risk similarly by sex. Male and female had HR of incident PD with OSA of 1.56 (95% CI, 1.30-1.87) and 1.60 (95% CI, 1.21-2.11), respectively. The incidence of OSA did not increase in PD patients (OR 0.89, 95% CI, 0.53-1.49). The MD of apnea-hypopnea index (AHI) in PD patients was also not statistically significant (P = 0.5).

CONCLUSIONS

The results indicate that OSA is one of independent risk factors of PD. However, OSA does not seem to be abnormally frequent in PD.

摘要

背景

阻塞性睡眠呼吸暂停（OSA）是帕金森病（PD）中常见的睡眠障碍。然而，OSA 与 PD 之间的关系仍然不一致。我们的研究旨在评估 PD 和 OSA 之间的关系。

方法

使用 PubMed、Embase、Web of Science、Cochrane 图书馆和中国国家知识基础设施数据库搜索 OSA 和 PD 的研究。使用 Review Manager 5.3 软件计算汇总估计效应。使用方差倒数模型汇总平均差（MD）或风险比（HR）；Mantel-Haenszel 方法用于汇总比值比（OR）。使用 I 统计量和 Q 检验评估研究之间的异质性。

结果

共有 12 项研究，93332 例患者符合纳入标准并纳入荟萃分析。总体而言，OSA 患者 PD 的发生率更高（HR 1.59，95%CI，1.36-1.85）。亚组分析表明，性别也存在同样的风险。患有 OSA 的男性和女性发生 PD 的 HR 分别为 1.56（95%CI，1.30-1.87）和 1.60（95%CI，1.21-2.11）。PD 患者的 OSA 发生率并未增加（OR 0.89，95%CI，0.53-1.49）。PD 患者的呼吸暂停低通气指数（AHI）MD 也无统计学意义（P=0.5）。