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利巴韦林与沙粒病毒进入抑制剂LHF-535联合使用可增强针对真实拉沙病毒的抗病毒效果。

Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus.

作者信息

Peng Cheng, Hu Jialing, Bai Yuan, Wu Wei, Mao Wenting, Liu Yang, Wan Yi, Zhang Lei, Li Wei, Tian Tingting, Liu Tiezhu, Wang Yanhai, Liang Mifang, Han Jun, Yuan Zhiming, Li Jiandong, Shan Chao, Deng Fei, Wang Wei

机构信息

State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.

State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of the Chinese Academy of Sciences, Beijing, 100049, China.

出版信息

Virol Sin. 2025 Jun;40(3):491-494. doi: 10.1016/j.virs.2025.04.003. Epub 2025 Apr 12.

DOI:10.1016/j.virs.2025.04.003
PMID:40228742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12282416/
Abstract

• A new strain of Lassa virus (LASV) was successfully isolated and characterized. • The combination of ribavirin and LHF-535 has been demonstrated to exhibit synergistic effects in inhibiting LASV. • The findings provide new directions for the development of antiviral drugs and vaccines for Lassa fever.

摘要

• 一种新型拉沙病毒（LASV）被成功分离并鉴定。

• 已证明利巴韦林和LHF-535联合使用在抑制拉沙病毒方面具有协同作用。

• 这些发现为拉沙热抗病毒药物和疫苗的研发提供了新方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/fd0c12e3051e/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/342e031861bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/854ea8d6f5b9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/fd0c12e3051e/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/342e031861bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/854ea8d6f5b9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f9/12282416/fd0c12e3051e/figs1.jpg

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Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus.利巴韦林与沙粒病毒进入抑制剂LHF-535联合使用可增强针对真实拉沙病毒的抗病毒效果。
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本文引用的文献

1
The first imported case of Lassa fever in China: a case description.中国首例输入性拉沙热病例：病例描述
Quant Imaging Med Surg. 2025 Jan 2;15(1):1066-1072. doi: 10.21037/qims-24-1784. Epub 2024 Nov 22.
2
Coadministration of LHF-535 and favipiravir protects against experimental Junín virus infection and disease.LHF-535与法匹拉韦联合用药可预防实验性胡宁病毒感染和疾病。
Antiviral Res. 2024 Sep;229:105952. doi: 10.1016/j.antiviral.2024.105952. Epub 2024 Jun 28.
3
Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry.
己烯雌酚，一种雌激素受体激动剂，可抑制拉沙病毒进入。
J Virol. 2024 Jul 23;98(7):e0071424. doi: 10.1128/jvi.00714-24. Epub 2024 May 29.
4
A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle.一种新型的 BSL-2 拉沙病毒反向遗传系统，模拟完整的病毒生命周期。
Emerg Microbes Infect. 2024 Dec;13(1):2356149. doi: 10.1080/22221751.2024.2356149. Epub 2024 Jun 10.
5
Lassa Fever Natural History and Clinical Management.拉沙热自然史与临床管理。
Curr Top Microbiol Immunol. 2023;440:165-192. doi: 10.1007/82_2023_263.
6
Safety and Pharmacokinetics of LHF-535, a Potential Treatment for Lassa Fever, in Healthy Adults.LHF-535 治疗拉沙热的安全性和药代动力学研究：一项在健康成年人中的研究。
Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0095122. doi: 10.1128/aac.00951-22. Epub 2022 Oct 31.
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Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.利巴韦林治疗拉沙热的药代动力学：尼日利亚埃多州 Irrua 教学专科医院的观察性临床研究。
Clin Infect Dis. 2023 Feb 8;76(3):e841-e848. doi: 10.1093/cid/ciac578.
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Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies.缺乏利巴韦林治疗拉沙热的证据：已发表和未发表研究的系统评价。
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9
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