Abi-Rizk Alain, Ghorayeb Elie, El Hage Jeanne
Department of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Lebanon.
Department of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Lebanon.
Microb Pathog. 2025 Jul;204:107581. doi: 10.1016/j.micpath.2025.107581. Epub 2025 Apr 12.
In the spring of 2023, several "broiler breeder" and "broiler" farms in North Lebanon were affected by a disease that impaired general performance and caused severe daily mortalities. Despite antibiotic treatments, there was no significant improvement. Serological analysis indicated that the flocks were protected against Infectious Bursal Disease (IBD), Infectious Bronchitis Virus (IBV), Avian Influenza (AI), and Newcastle Disease Virus (NDV). However, necropsy revealed severe liver lesions and swollen kidneys. This study investigated the possible presence of avian adenovirus (FAdV), which causes inclusion body hepatitis, and avastrovirus (AstV), which causes hepatitis and runting stunting syndrome, in Lebanese breeders and broilers. For the first time, a co-infection between FAdV and AstV was described. Both viruses were detected by PCR and RT-PCR. DNA sequencing identified the FAdV as adenovirus E type 8b and adenovirus D type 2 and the AstV as avastrovirus type 2. This comprehensive study identified the primary cause of the atypical body inclusion hepatitis and runting stunting syndrome observed in North Lebanon.
2023年春季，黎巴嫩北部的几家“种鸡场”和“肉鸡场”受到一种疾病的影响，该疾病损害了鸡的总体性能并导致严重的每日死亡率。尽管进行了抗生素治疗，但情况没有明显改善。血清学分析表明，鸡群对传染性法氏囊病（IBD）、传染性支气管炎病毒（IBV）、禽流感（AI）和新城疫病毒（NDV）具有抵抗力。然而，尸检显示肝脏有严重病变且肾脏肿大。本研究调查了黎巴嫩种鸡和肉鸡中可能存在的禽腺病毒（FAdV，可引起包涵体肝炎）和星状病毒（AstV，可引起肝炎和矮小综合征）。首次描述了FAdV和AstV的共同感染。通过PCR和RT-PCR检测到了这两种病毒。DNA测序确定FAdV为8b型腺病毒和2型腺病毒D，AstV为2型星状病毒。这项全面的研究确定了在黎巴嫩北部观察到的非典型包涵体肝炎和矮小综合征的主要病因。
