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Growing adoption of pharmacologic maintenance therapy after allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a survey on behalf of the EBMT acute leukemia working party.

作者信息

Abou Dalle Iman, Labopin Myriam, Khvedelidze Irma, Baron Frédéric, Brissot Eolia, Bug Gesine, Esteve Jordi, Giebel Sebastian, Gorin Norbert-Claude, Lanza Francesco, Nagler Arnon, Peric Zina, Piemontese Simona, Ruggeri Annalisa, Sanz Jaime, Savani Bipin, Schmid Christoph, Shouval Roni, Spyridonidis Alexandros, Versluis Jurjen, Ciceri Fabio, Bazarbachi Ali, Mohty Mohamad

机构信息

Bone marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Hospital Saint-Antoine, Sorbonne University; Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Paris, France.

出版信息

Bone Marrow Transplant. 2025 Apr 15. doi: 10.1038/s41409-025-02576-4.

DOI:10.1038/s41409-025-02576-4
PMID:40229537
Abstract
摘要

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Growing adoption of pharmacologic maintenance therapy after allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a survey on behalf of the EBMT acute leukemia working party.急性髓系白血病异基因造血细胞移植后药物维持治疗的应用日益增加：代表欧洲血液与骨髓移植协会急性白血病工作组进行的一项调查
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Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission: a retrospective survey on behalf of the ALWP of the EBMT.单倍体核型作为首次完全缓解期接受异基因造血干细胞移植治疗的急性髓系白血病患者的不良预后因素：代表欧洲血液与骨髓移植协会急性白血病工作组进行的一项回顾性调查
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Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management.急性髓系白血病：诊断、治疗与管理的最新进展
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本文引用的文献

1
Gilteritinib as Post-Transplant Maintenance for AML With Internal Tandem Duplication Mutation of .吉特替尼作为伴有. 内部串联重复突变的 AML 移植后维持治疗。
J Clin Oncol. 2024 May 20;42(15):1766-1775. doi: 10.1200/JCO.23.02474. Epub 2024 Mar 12.
2
Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML.低强度预处理异基因移植后用 venetoclax/阿扎胞苷进行预防性维持治疗高危 MDS 和 AML。
Blood Adv. 2024 Feb 27;8(4):978-990. doi: 10.1182/bloodadvances.2023012120.
3
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology.
急性髓系白血病，第 3 版 2023 年，NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2023 May;21(5):503-513. doi: 10.6004/jnccn.2023.0025.
4
Allogeneic Stem Cell Transplantation for FLT3-Mutated Acute Myeloid Leukemia: T-Cell Depletion and Posttransplant Sorafenib Maintenance Improve Survival. A Retrospective Acute Leukemia Working Party-European Society for Blood and Marrow Transplant Study.FLT3突变型急性髓系白血病的异基因干细胞移植：T细胞清除和移植后索拉非尼维持治疗可改善生存率。一项急性白血病工作组-欧洲血液和骨髓移植学会的回顾性研究。
Clin Hematol Int. 2019 Mar 18;1(1):58-74. doi: 10.2991/chi.d.190310.001. eCollection 2019 Mar.
5
A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients.一项针对高危急性髓系白血病（AML）和骨髓增生异常综合征（MDS）患者移植后5-氮杂胞苷维持治疗与观察的3期随机研究。
Blood Adv. 2020 Nov 10;4(21):5580-5588. doi: 10.1182/bloodadvances.2020002544.
6
Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial.索拉非尼维持治疗伴 FLT3-ITD 急性髓系白血病行异基因造血干细胞移植患者：一项开放标签、多中心、随机 3 期临床试验。
Lancet Oncol. 2020 Sep;21(9):1201-1212. doi: 10.1016/S1470-2045(20)30455-1. Epub 2020 Aug 10.
7
Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With -Internal Tandem Duplication Mutation (SORMAIN).异基因造血干细胞移植治疗伴有内部串联重复突变的急性髓系白血病后的索拉非尼维持治疗（SORMAIN）。
J Clin Oncol. 2020 Sep 10;38(26):2993-3002. doi: 10.1200/JCO.19.03345. Epub 2020 Jul 16.
8
Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with -internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.伴有内部串联重复的急性髓系白血病患者造血干细胞移植的临床实践推荐：欧洲血液与骨髓移植学会急性白血病工作组的立场声明
Haematologica. 2020 Jun;105(6):1507-1516. doi: 10.3324/haematol.2019.243410. Epub 2020 Apr 2.
9
Distinct factors determine the kinetics of disease relapse in adults transplanted for acute myeloid leukaemia.不同因素决定了成人急性髓系白血病移植后疾病复发的动力学。
J Intern Med. 2018 Apr;283(4):371-379. doi: 10.1111/joim.12720. Epub 2018 Jan 5.