Yang Sen, Wang Yuan, Huang Sisi, Zhang Tong, Xu Pinglong, Jiang Chao, Ye Cunqi
Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Nat Chem Biol. 2025 Apr 14. doi: 10.1038/s41589-025-01885-5.
Biological timing is a fundamental aspect of life, facilitating efficient resource use and adaptation to environmental changes. In this study, we unveil robust temporal oscillations in phospholipid abundance as a function of the yeast metabolic cycle (YMC). These fluctuations, occurring throughout the cell division cycle, demonstrate a systematic segregation of various phospholipid species over time. Such segregation corresponds logically with their physical properties, generating entropic forces for membrane dynamics and biogenesis. Within the YMC, the temporal oscillations in phosphatidylethanolamine and phosphatidylcholine levels require biosynthesis from triacylglycerol as a crucial lipid reservoir, with phosphatidylinositol and phosphatidylserine synthesized primarily de novo. The orchestrated regulation of gene expression in biosynthesis pathways ensures precise temporal control of phospholipid dynamics, ultimately promoting metabolic efficiency.
生物节律是生命的一个基本方面，有助于高效利用资源和适应环境变化。在本研究中，我们揭示了磷脂丰度随酵母代谢周期（YMC）而出现的强烈时间振荡。这些波动在整个细胞分裂周期中发生，表明各种磷脂种类随时间的系统性分离。这种分离在逻辑上与其物理性质相对应，为膜动力学和生物合成产生熵力。在YMC内，磷脂酰乙醇胺和磷脂酰胆碱水平的时间振荡需要以三酰甘油作为关键脂质储备进行生物合成，而磷脂酰肌醇和磷脂酰丝氨酸主要是从头合成。生物合成途径中基因表达的协调调控确保了磷脂动力学的精确时间控制，最终提高了代谢效率。
