Zhao Bo, Wei Jiping, Jiang Zijian, Long Yiming, Xu Yan, Jiang Botao
School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, 437100, Hubei Province, P. R. China.
Department of Urology, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology, 228 Jingui Road, Xian an District, Xianning, 437100, Hubei Province, P. R. China.
Stem Cell Res Ther. 2025 Apr 14;16(1):178. doi: 10.1186/s13287-025-04302-9.
Hepatic ischemia-reperfusion injury (HIRI) severely threatens the success rates of liver surgery and transplantation. Its complex pathological process involves multiple factors such as oxidative stress, inflammatory responses, and ferroptosis, creating an urgent need for new therapeutic strategies. Exosomes derived from mesenchymal stem cells (MSCs) are emerging as a next-generation acellular therapeutic approach. With their outstanding immune-regulatory capabilities, significant reparative functions, and good biocompatibility, they are leading innovations in the field of HIRI treatment. This article provides a systematic comparison of the therapeutic characteristics of MSC-derived exosomes(MSC-EXOs) from four different sources: adipose tissue, bone marrow, umbilical cord, and induced pluripotent stem cells. Although the clinical translation of MSC-EXOs still faces challenges such as variations in isolation methods, large-scale production, and safety assessments, their remarkable therapeutic effects and vast application potential signal the arrival of a new era of precision treatment for HIRI. This review not only provides a comprehensive theoretical foundation to promote the clinical application of MSC-EXOs but also opens up innovative research directions in the field of regenerative medicine.
肝缺血再灌注损伤（HIRI）严重威胁着肝脏手术和移植的成功率。其复杂的病理过程涉及氧化应激、炎症反应和铁死亡等多种因素，迫切需要新的治疗策略。源自间充质干细胞（MSC）的外泌体正在成为一种新一代的无细胞治疗方法。凭借其出色的免疫调节能力、显著的修复功能和良好的生物相容性，它们引领着HIRI治疗领域的创新。本文系统比较了来自脂肪组织、骨髓、脐带和诱导多能干细胞这四种不同来源的MSC衍生外泌体（MSC-EXOs）的治疗特性。尽管MSC-EXOs的临床转化仍面临分离方法差异、大规模生产和安全性评估等挑战，但其显著的治疗效果和巨大的应用潜力预示着HIRI精准治疗新时代的到来。这篇综述不仅为促进MSC-EXOs的临床应用提供了全面的理论基础，也为再生医学领域开辟了创新研究方向。
