Boisvert Mélanie, Dugré Jules R, Potvin Stéphane
Research Center of the Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada.
Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, Canada.
Early Interv Psychiatry. 2025 Apr;19(4):e70042. doi: 10.1111/eip.70042.
We aimed to identify if offspring of a parent with mood disorders presented cognitive deficits on 14 cognitive subtests while controlling for intellectual quotient, anxio-depressive symptoms, symptoms of attention deficit hyperactivity disorder (ADHD) or insomnia.
Using the Healthy Brain Network biobank, we identified 44 offspring of a parent with bipolar disorder (BD), 87 offspring of a parent with major depressive disorder (MDD) and 88 offspring of healthy parents. Analyses of variance (ANOVA) were performed to determine if groups differed on 14 subtests of the Wechsler Intelligence Scale for Children-5th Edition (WISC) and National Institutes of Health toolbox.
Across all subtests, groups did not significantly differ. Only a subtle effect was found for male participants in which high-risk participants exhibited lower scores on the mental rotation subtest compared to the control group.
Overall, our results suggest intact cognition in young offspring of parents with a mood disorder.
我们旨在确定患有情绪障碍的父母的后代在14项认知子测试中是否存在认知缺陷，同时控制智商、焦虑抑郁症状、注意力缺陷多动障碍（ADHD）症状或失眠。
利用健康大脑网络生物样本库，我们确定了44名患有双相情感障碍（BD）的父母的后代、87名患有重度抑郁症（MDD）的父母的后代和88名健康父母的后代。进行方差分析（ANOVA）以确定这些组在韦氏儿童智力量表第五版（WISC）和美国国立卫生研究院工具箱的14项子测试中是否存在差异。
在所有子测试中，各组之间没有显著差异。仅在男性参与者中发现了一个细微的效应，即与对照组相比，高风险参与者在心理旋转子测试中的得分较低。
总体而言，我们的结果表明患有情绪障碍的父母的年幼后代认知功能完好。
