Kubos K L, Brady J V, Moran T H, Smith C H, Robinson R G
Pharmacol Biochem Behav. 1985 Jun;22(6):1001-6. doi: 10.1016/0091-3057(85)90309-0.
Male Sprague Dawley rats received unilateral 1.5 mm diameter focal suction lesions of either the left or right orbito-frontal cortex and were tested for response to 6 doses of amphetamine sulfate ranging from 0.5 to 1.5 mg/kg on a DRL-20 schedule of reinforcement. Right hemispheric lesion animals obtained a greater number of control reinforcements and were more sensitive to amphetamine's disruptive effects, showing a greater dose-related decrease in water rewards obtained than left lesion animals. An analysis method is introduced which combines the interactive effects of premature responses and their IRT value in a way that relates directly to reinforcement attainment. Calculated total session time made unavailable for reinforcement due to premature responding, correlated negatively (r = -.942) with the number of reinforcements obtained.
雄性斯普拉格-道利大鼠接受了左侧或右侧眶额叶皮质直径1.5毫米的单侧局灶性抽吸损伤，并在DRL-20强化程序下测试了对6种剂量（0.5至1.5毫克/千克）硫酸苯丙胺的反应。右侧半球损伤的动物获得了更多的对照强化，并且对苯丙胺的干扰作用更敏感，与左侧损伤动物相比，在获得的水奖励方面显示出更大的剂量相关减少。引入了一种分析方法，该方法以与强化获得直接相关的方式结合了过早反应及其IRT值的交互作用。由于过早反应而导致无法用于强化的计算总会话时间与获得的强化次数呈负相关（r = -0.942）。
