Seiden L S, Andresen J, MacPhail R C
Pharmacol Biochem Behav. 1979 Apr;10(4):577-84. doi: 10.1016/0091-3057(79)90236-3.
The effects of d-amphetamine and methylphenidate and their interactions with amine-depleting drugs were examined in rats trained to press a lever to obtain water reinforcement on a schedule that differentially reinforced responding at low rates (DRL). Both methylphenidate (2.5-20.0 mg/kg) and d-amphetamine (0.375-3.0 mg/kg) increased the rate of responding and decreased the frequency of reinforcement on the DRL schedule. Both drugs also shifted the interresponse time (IRT) distributions to the left such that the modal IRT occurred well below the minimum IRT required for reinforcement (d-amphetamine was abut eight times more potent than methylphenidate for each of these effects). The effects of both d-amphetamine and methylphenidate on DRL performance were attenuated by administration of alphamethyltyrosine (AMT) (150 mg/kg) and both drugs attenuated the response rate-suppressing effects of tetrabenazine (TBZ) (4.0 mg/kg). The similarity of the drug interactions between methylphenidate or amphetamine and AMT or TBZ suggest that the doses of methylphenidate and d-amphetamine examined act on similar catecholaminergic pools with the central nervous system to influence DRL performance.
在训练大鼠按杠杆以获取水强化物的实验中，按照低比率差异强化反应（DRL）的程序，研究了右旋苯丙胺和哌醋甲酯的作用及其与耗胺类药物的相互作用。哌醋甲酯（2.5 - 20.0毫克/千克）和右旋苯丙胺（0.375 - 3.0毫克/千克）均增加了反应速率，并降低了DRL程序中的强化频率。两种药物还使反应间隔时间（IRT）分布向左移动，使得最常见的IRT远低于强化所需的最短IRT（就这些效应而言，右旋苯丙胺的效力约为哌醋甲酯的八倍）。给予α-甲基酪氨酸（AMT）（150毫克/千克）可减弱右旋苯丙胺和哌醋甲酯对DRL表现的影响，且两种药物均可减弱丁苯那嗪（TBZ）（4.0毫克/千克）对反应速率的抑制作用。哌醋甲酯或苯丙胺与AMT或TBZ之间药物相互作用的相似性表明，所研究的哌醋甲酯和右旋苯丙胺剂量作用于中枢神经系统中相似的儿茶酚胺能池，以影响DRL表现。
