Feng Xujun, Zhang Ye, Shi Yuan, Ren Rong, Lei Fei, Vitiello Micheal V, Tang Xiangdong
Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
These authors share the first authorship.
ERJ Open Res. 2025 Apr 14;11(2). doi: 10.1183/23120541.00682-2024. eCollection 2025 Mar.
This meta-analysis examines the clinical characteristics of continuous positive airway pressure (CPAP)-treated obstructive sleep apnoea (OSA) patients with residual excessive sleepiness (RES).
We conducted a search for articles published from inception to 16 March 2024 in PubMed, Embase, Cochrane Library and Web of Science. Seven studies were included in this meta-analysis.
The meta-analysis revealed that CPAP-treated OSA patients with RES were characterised by higher Epworth sleepiness scale and depression scale scores, lower body mass index (BMI) and apnoea-hypopnoea index (AHI) before CPAP treatment. RES patients also exhibit poorer CPAP adherence. Being female was also associated with RES.
Being female, having lower BMI and AHI, more severe daytime sleepiness and depressive symptoms before CPAP treatment, and lower CPAP adherence were characteristics of OSA patients with RES. These factors may prove helpful in identifying CPAP-treated OSA patients who may need additional treatment to minimise RES.
本荟萃分析探讨持续气道正压通气（CPAP）治疗的阻塞性睡眠呼吸暂停（OSA）患者伴有残余过度嗜睡（RES）的临床特征。
我们检索了从创刊至2024年3月16日在PubMed、Embase、Cochrane图书馆和科学网发表的文章。本荟萃分析纳入了7项研究。
荟萃分析显示，CPAP治疗的伴有RES的OSA患者的特征为，在CPAP治疗前，Epworth嗜睡量表和抑郁量表得分较高，体重指数（BMI）和呼吸暂停低通气指数（AHI）较低。RES患者的CPAP依从性也较差。女性也与RES有关。
女性、BMI和AHI较低、CPAP治疗前白天嗜睡和抑郁症状较严重以及CPAP依从性较低是伴有RES的OSA患者的特征。这些因素可能有助于识别CPAP治疗的OSA患者中可能需要额外治疗以尽量减少RES的患者。
