应激负荷是一种累积生理应激的指标，它会损害老年人的脑结构，但不会影响其积累：一项探索性研究。
Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not -accumulation in older adults: an exploratory study.
作者信息
Palix Cassandre, Chauveau Léa, Felisatti Francesca, Chocat Anne, Coulbault Laurent, Hébert Oriane, Mézenge Florence, Landeau Brigitte, Haudry Sacha, Fauvel Séverine, Collette Fabienne, Klimecki Olga, Marchant Natalie L, De La Sayette Vincent, Vivien Denis, Chételat Gaël, Poisnel Géraldine
机构信息
Normandie University, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Cyceron, Caen, France.
Department of Biochemistry, Caen Normandy Hospital (CHU de Caen), Caen, France.
出版信息
Front Aging Neurosci. 2025 Mar 31;17:1508677. doi: 10.3389/fnagi.2025.1508677. eCollection 2025.
INTRODUCTION
Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.
METHODS
At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.
RESULTS
AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.
DISCUSSION
AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
引言
应激负荷（AL）是长期暴露于日常压力下渐进性生理失调的综合评分。尽管关注度不断提高，但在健康老年人群中，采用多模式方法研究其与衰老的大脑和认知方面以及阿尔茨海默病（AD）敏感标志物之间联系的研究仍很有限。
方法
在基线时，来自“健康老龄化”试验的111名老年人（无认知障碍）在3个月内完成了血液和人体测量指标采集、认知评估及多模式神经成像。
结果
应激负荷与额叶和颞叶区域的灰质体积、白质完整性呈负相关，且注意力表现较差。
讨论
应激负荷与衰老和压力敏感区域的脑结构完整性相关，但与AD相关标志物（淀粉样蛋白负荷）无关，且仅在老年人的两个AD敏感脑区相关。这些结果凸显了应激负荷作为应激诱导脑衰老敏感指标的潜在价值。
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