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肥胖和体重正常的结直肠肿瘤患者的肠道微生物群和代谢组特征

Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.

作者信息

La Vecchia Marta, Clavenna Michela Giulia, Sculco Marika, Sala Gloria, Marradi Denise, Barberis Elettra, Joseph Soni, Mellai Marta, Pagano Nico, Boldorini Renzo, Azzimonti Barbara, Bona Elisa, Pasolli Edoardo, Prodam Flavia, Sacerdote Carlotta, Ferrante Daniela, Ghelardi Emilia, Manfredi Marcello, Aspesi Anna, Dianzani Irma

机构信息

Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.

Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.

出版信息

iScience. 2025 Mar 13;28(4):112221. doi: 10.1016/j.isci.2025.112221. eCollection 2025 Apr 18.

DOI:10.1016/j.isci.2025.112221
PMID:40230532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995084/
Abstract

Here, we aim to improve our understanding of various colorectal cancer (CRC) risk factors (obesity, unhealthy diet, and gut microbiota/metabolome alteration), analyzing 120 patients with colon polyps, divided in normal-weight (NW) or overweight/obese (OB). Dietary habits data (validated EPIC questionnaires) revealed a higher consumption of processed meat among OB vs. NW patients. Both mucosa-associated microbiota (MAM) on polyps and lumen-associated microbiota (LAM) analyses uncovered distinct bacterial signatures in the two groups. Importantly, we found an enrichment of the pathogenic species in MAM of OB patients, regardless of their polyp stage. We observed distinct mucosal-associated metabolome signatures, with OB patients showing increased pyroglutamic acid and reduced niacin levels, and performed microbiota-metabolome integrated analysis. These findings support a model where different risk factors may contribute to tumorigenesis in OB vs. NW patients, highlighting the potential impact of processed meat consumption and on CRC development among OB patients.

摘要

在此，我们旨在加深对各种结直肠癌（CRC）风险因素（肥胖、不健康饮食以及肠道微生物群/代谢组改变）的理解，对120例结肠息肉患者进行分析，这些患者分为正常体重（NW）组或超重/肥胖（OB）组。饮食习惯数据（经过验证的EPIC问卷）显示，与NW组患者相比，OB组患者加工肉类的摄入量更高。息肉上的黏膜相关微生物群（MAM）和肠腔相关微生物群（LAM）分析均揭示了两组中不同的细菌特征。重要的是，我们发现OB组患者的MAM中致病菌种富集，无论其息肉处于何种阶段。我们观察到不同的黏膜相关代谢组特征，OB组患者焦谷氨酸水平升高，烟酸水平降低，并进行了微生物群-代谢组综合分析。这些发现支持了一种模型，即不同的风险因素可能在OB组与NW组患者的肿瘤发生中起作用，突出了加工肉类消费对OB组患者结直肠癌发展的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/e33ffa0ca0f8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/251cdd563e18/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/406abf1de469/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/3d97f369df03/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/9824f294badd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/e33ffa0ca0f8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/251cdd563e18/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/406abf1de469/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/3d97f369df03/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/9824f294badd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/11995084/e33ffa0ca0f8/gr4.jpg

相似文献

[1]
Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.

iScience. 2025-3-13

[2]
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Cancers (Basel). 2023-6-6

[3]
A Comparative Study of Serum Biochemistry, Metabolome and Microbiome Parameters of Clinically Healthy, Normal Weight, Overweight, and Obese Companion Dogs.

Top Companion Anim Med. 2018-12

[4]
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mBio. 2020-2-18

[5]
Gut microbiota signatures in tissues of the colorectal polyp and normal colorectal mucosa, and faeces.

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[6]
Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets.

Microbiome. 2024-9-27

[7]
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Int J Mol Sci. 2024-12-11

[8]
Impact of Extreme Obesity and Diet-Induced Weight Loss on the Fecal Metabolome and Gut Microbiota.

Mol Nutr Food Res. 2021-3

[9]
Development of a simultaneous quantification method for the gut microbiota-derived core nutrient metabolome in mice and its application in studying host-microbiota interaction.

Anal Chim Acta. 2023-4-22

[10]
Compliance with Nutritional Recommendations and Gut Microbiota Profile in Galician Overweight/Obese and Normal-Weight Individuals.

Nutrients. 2023-8-1

本文引用的文献

[1]
Study of Microbiota Associated to Early Tumors Can Shed Light on Colon Carcinogenesis.

Int J Mol Sci. 2024-12-11

[2]
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis.

Clin Exp Med. 2024-10-29

[3]
Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3.

BMC Gastroenterol. 2024-3-14

[4]
Distinct Signatures of Tumor-Associated Microbiota and Metabolome in Low-Grade vs. High-Grade Dysplastic Colon Polyps: Inference of Their Role in Tumor Initiation and Progression.

Cancers (Basel). 2023-6-6

[5]
Indole metabolites and colorectal cancer: Gut microbial tryptophan metabolism, host gut microbiome biomarkers, and potential intervention mechanisms.

Microbiol Res. 2023-7

[6]
Independent and joint associations of general and abdominal obesity with the risk of conventional adenomas and serrated polyps: A large population-based study in East Asia.

Int J Cancer. 2023-7-1

[7]
Gut microbiota analysis for prediction of clinical relapse in Crohn's disease.

Sci Rep. 2022-11-19

[8]
Discovery and Validation of Potential Serum Biomarkers with Pro-Inflammatory and DNA Damage Activities in Ulcerative Colitis: A Comprehensive Untargeted Metabolomic Study.

Metabolites. 2022-10-20

[9]
Microbiology and Epidemiology of -An Emerging Elusive Foodborne Pathogen.

Microorganisms. 2022-4-22

[10]
Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects.

Front Oncol. 2022-2-11

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