Bai Hao, Xu Zenghao, Li Jiayu, Zhang Xiaocong, Gao Kai, Fei Xinglin, Yang Jinhua, Li Qilong, Qian Sangni, Zhang Wanting, Gao Xiangrong, Tang Mengling, Wang Jianbing, Chen Kun, Jin Mingjuan
Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Epidemiology, Zhejiang Chinese Medical University School of Public Health, Hangzhou, China.
Int J Cancer. 2023 Jul 1;153(1):54-63. doi: 10.1002/ijc.34503. Epub 2023 Mar 27.
Evidence regarding associations of general and abdominal obesity with the risk of conventional adenomas (ADs) and serrated polyps (SPs) from Asian population is scarce. Our study aimed to investigate the independent and joint associations of general obesity assessed by body mass index (BMI) and abdominal obesity assessed by waist circumference (WC) or waist-to-hip ratio (WHR) with the risk of ADs and SPs among 25 222 participants recruited by a population-based screening program. Compared to participants with normal BMI, those with a BMI ≥28 kg/m had increased risk of ADs (odds ratio [OR] 1.52, 95% confidence interval [CI]: 1.36-1.70) and SPs (OR 1.69, 95% CI: 1.38-2.07). For participants with a WC ≥102 cm (≥88 cm for females), the risk of ADs (OR 1.37, 95% CI: 1.25-1.51) and SPs (OR 1.81, 95% CI: 1.52-2.16) was higher than that of the reference group. For participants with a WHR ≥0.95 (≥0.90 for females), the risk of ADs (OR 1.26, 95% CI: 1.16-1.36) and SPs (OR 1.46, 95% CI: 1.26-1.69) was higher than that of the reference group. Moreover, participants with both BMI ≥28 kg/m and WC ≥102 cm (≥88 cm for females) had 61% and 119% higher risk of ADs (OR 1.61, 95% CI: 1.39-1.85) and SPs (OR 2.19, 95% CI: 1.70-2.82) compared to those with both normal BMI and WC. These findings indicate that both general and abdominal obesity are associated with SPs and ADs, presenting stronger association with SPs than ADs. Moreover, the association is more evident when both obesities exist.
关于亚洲人群中一般肥胖和腹型肥胖与传统腺瘤（ADs）和锯齿状息肉（SPs）风险之间关联的证据很少。我们的研究旨在调查在一项基于人群的筛查项目招募的25222名参与者中，通过体重指数（BMI）评估的一般肥胖以及通过腰围（WC）或腰臀比（WHR）评估的腹型肥胖与ADs和SPs风险之间的独立关联和联合关联。与BMI正常的参与者相比，BMI≥28kg/m²的参与者患ADs（比值比[OR]1.52，95%置信区间[CI]：1.36 - 1.70）和SPs（OR 1.69，95%CI：1.38 - 2.07）的风险增加。对于WC≥102cm（女性≥88cm）的参与者，ADs（OR 1.37，95%CI：1.25 - 1.51）和SPs（OR 1.81，95%CI：1.52 - 2.16）的风险高于参考组。对于WHR≥0.95（女性≥0.90）的参与者，ADs（OR 1.26，95%CI：1.16 - 1.36）和SPs（OR 1.46，95%CI：1.26 - 1.69）的风险高于参考组。此外，与BMI和WC均正常的参与者相比，BMI≥28kg/m²且WC≥102cm（女性≥88cm）的参与者患ADs（OR 1.61，95%CI：1.39 - 1.85）和SPs（OR 2.19，95%CI：1.70 - 2.82）的风险分别高61%和119%。这些发现表明，一般肥胖和腹型肥胖均与SPs和ADs相关，与ADs相比，与SPs的关联更强。此外，当两种肥胖同时存在时，这种关联更为明显。
