Li Jing, Zhang Ai-Hua, Wu Fang-Fang, Wang Xi-Jun
National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plant, Nanning, China.
National Chinmedomics Research Center, National Traditional Chinese Medicine (TCM) Key Laboratory of Serum Pharmacochemistry, Functional Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Front Oncol. 2022 Feb 11;12:841552. doi: 10.3389/fonc.2022.841552. eCollection 2022.
Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide. The etiology and pathogenesis of CRC remain unclear. A growing body of evidence suggests dysbiosis of gut bacteria can contribute to the occurrence and development of CRC by generating harmful metabolites and changing host physiological processes. Metabolomics, a systems biology method, will systematically study the changes in metabolites in the physiological processes of the body, eventually playing a significant role in the detection of metabolic biomarkers and improving disease diagnosis and treatment. Metabolomics, in particular, has been highly beneficial in tracking microbially derived metabolites, which has substantially advanced our comprehension of host-microbiota metabolic interactions in CRC. This paper has briefly compiled recent research progress of the alterations of intestinal flora and its metabolites associated with CRC and the application of association analysis of metabolomics and gut microbiome in the diagnosis, prevention, and treatment of CRC; furthermore, we discuss the prospects for the problems and development direction of this association analysis in the study of CRC. Gut microbiota and their metabolites influence the progression and causation of CRC, and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.
结直肠癌（CRC）是全球癌症发病和死亡的主要原因之一。CRC的病因和发病机制仍不清楚。越来越多的证据表明，肠道细菌生态失调可通过产生有害代谢产物和改变宿主生理过程，促进CRC的发生和发展。代谢组学作为一种系统生物学方法，将系统地研究机体生理过程中代谢产物的变化，最终在代谢生物标志物的检测以及改善疾病诊断和治疗方面发挥重要作用。特别是，代谢组学在追踪微生物衍生的代谢产物方面非常有益，这极大地推进了我们对CRC中宿主-微生物群代谢相互作用的理解。本文简要综述了与CRC相关的肠道菌群及其代谢产物变化的最新研究进展，以及代谢组学与肠道微生物组关联分析在CRC诊断、预防和治疗中的应用；此外，我们还讨论了这种关联分析在CRC研究中存在的问题和发展方向的前景。肠道微生物群及其代谢产物影响CRC的进展和病因，代谢组学与肠道微生物组的关联分析将为CRC的预防、诊断和治疗提供新的策略。
