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本文引用的文献

1
Genomic Classification and Individualized Prognosis in Multiple Myeloma.多发性骨髓瘤的基因组分类和个体化预后。
J Clin Oncol. 2024 Apr 10;42(11):1229-1240. doi: 10.1200/JCO.23.01277. Epub 2024 Jan 9.
2
Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma.多发性骨髓瘤患者不可持续的可测量残留疾病阴性的预测因素。
Blood. 2024 Feb 15;143(7):592-596. doi: 10.1182/blood.2023022080.
3
Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma.适合移植的多发性骨髓瘤患者中不可持续的可测量残留疾病阴性的预测因素。
Blood. 2024 Feb 15;143(7):597-603. doi: 10.1182/blood.2023022083.
4
Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma.新诊断多发性骨髓瘤患者的临床结局和克隆性造血演变。
Cancer Res Commun. 2023 Dec 18;3(12):2560-2571. doi: 10.1158/2767-9764.CRC-23-0093.
5
Causes and consequences of clonal hematopoiesis.克隆性造血的原因和后果。
Blood. 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222.
6
Small myeloid subclones are present at diagnosis of multiple myeloma in patients who develop secondary myelodysplastic syndromes.在发展为继发性骨髓增生异常综合征的患者中，多发性骨髓瘤诊断时存在小的髓系亚克隆。
Haematologica. 2024 Apr 1;109(4):1289-1292. doi: 10.3324/haematol.2023.284050.
7
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance.大 T 细胞克隆表达免疫检查点在多发性骨髓瘤演变过程中增加，并预测治疗耐药性。
Nat Commun. 2023 Sep 20;14(1):5825. doi: 10.1038/s41467-023-41562-6.
8
Outcome of Second Primary Malignancies Developing in Multiple Myeloma Patients.多发性骨髓瘤患者发生的第二原发性恶性肿瘤的结局
Cancers (Basel). 2023 Sep 1;15(17):4359. doi: 10.3390/cancers15174359.
9
Maintenance lenalidomide in newly diagnosed transplant eligible and non-eligible myeloma patients; profiling second primary malignancies in 4358 patients treated in the Myeloma XI Trial.来那度胺维持治疗新诊断的适合和不适合移植的骨髓瘤患者；对骨髓瘤XI试验中4358例患者的第二原发性恶性肿瘤进行分析。
EClinicalMedicine. 2023 Jul 27;62:102099. doi: 10.1016/j.eclinm.2023.102099. eCollection 2023 Aug.
10
Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma.来那度胺和地塞米松维持治疗联合或不联合伊沙佐米，根据骨髓瘤患者的残留疾病状态进行调整。
Blood. 2023 Nov 2;142(18):1518-1528. doi: 10.1182/blood.2022019531.

突变造血祖细胞的动力学与多发性骨髓瘤的临床结局无关。

Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma.

作者信息

Guerrero Camila, Larrayoz Maria-Jose, Erdozain Irache, Puig Noemi, Cedena Maria-Teresa, Maia Catarina, Mañu Amagoia, Gordillo Natalia, Churruca Oihane, Alignani Diego, Sarvide Sarai, Vazquez Iria, Perez Cristina, Oriol Albert, Rosinol Laura, Ríos-Tamayo Rafael, Gonzalez-Perez Marta-Sonia, Gonzalez-Rodriguez Ana-Pilar, de Arriba Felipe, Moraleda Jose M, Martin Jesus, Palomera Luis, Cabañas Valentin, Calasanz Maria-Jose, Martinez-Lopez Joaquin, Mateos Maria-Victoria, Bladé Joan, Lahuerta Juan-Jose, San-Miguel Jesus F, Paiva Bruno

机构信息

Cancer Center Clinica Universidad de Navarra (CCUN), Cima Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain.

Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), CIBER-ONC number CB16/12/00233, Salamanca, Spain.

出版信息

Blood Cancer Discov. 2025 May 5;6(3):203-216. doi: 10.1158/2643-3230.BCD-24-0274.

DOI:10.1158/2643-3230.BCD-24-0274
PMID:40232156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12050965/
Abstract

SPMs that develop in patients with multiple myeloma have a deleterious impact on survival. Patients with CH may be at risk of developing SPMs, which could potentially be avoided through individualized treatment. However, our results suggest that screening for CH at diagnosis has limited utility.

摘要

多发性骨髓瘤患者发生的第二原发性恶性肿瘤（SPM）对生存有有害影响。CH患者可能有发生SPM的风险，通过个体化治疗有可能避免。然而，我们的结果表明，在诊断时筛查CH的效用有限。