记录复发情况：肛管癌中循环肿瘤人乳头瘤病毒DNA动力学

Clocking Recurrence: Circulating Tumor HPV DNA Kinetics in Anal Cancer.

作者信息

Bercz Aron, Faden Daniel L, Smith J Joshua, Romesser Paul B

机构信息

Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, York, New York.

Department of Otolaryngology, Head and Neck Cancer Surgery, Harvard Medical School, Mass Eye and Ear, Massachusetts General Hospital, Boston, Massachusetts.

出版信息

Clin Cancer Res. 2025 Jun 13;31(12):2261-2263. doi: 10.1158/1078-0432.CCR-25-0421.

DOI:10.1158/1078-0432.CCR-25-0421

PMID:40232195

Abstract

Detection of circulating tumor human papillomavirus (HPV) DNA 3 months after completing definitive chemoradiation for localized anal squamous cell carcinoma associates with disease recurrence and inferior recurrence-free survival. These findings provide valuable insights into the temporal significance of circulating tumor HPVDNA detection in anal cancer and its potential implications for early intervention. See related article by Morris et al., p. 2399.

摘要

对于局部晚期肛管鳞状细胞癌，在完成根治性放化疗3个月后检测循环肿瘤人乳头瘤病毒（HPV）DNA，其与疾病复发及无复发生存期较差相关。这些发现为肛管癌中循环肿瘤HPV DNA检测的时间意义及其对早期干预的潜在影响提供了有价值的见解。见Morris等人的相关文章，第2399页。