具有乳头样特征的人乳头瘤病毒相关肛管鳞状细胞癌。
Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features.
作者信息
Leon Marino E, Shamekh Rania, Coppola Domenico
机构信息
Marino E Leon, Domenico Coppola, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States.
出版信息
World J Gastroenterol. 2015 Feb 21;21(7):2210-3. doi: 10.3748/wjg.v21.i7.2210.
Human papillomavirus (HPV) related squamous cell carcinoma (SCC) involving the anal canal is a well-known carcinoma associated with high-risk types of HPV. HPV-related SCC with papillary morphology (papillary SCC) has been described in the oropharynx. We describe, for the first time, a case of anal HPV-related squamous carcinoma with papillary morphology. The tumor arose from the anal mucosa. The biopsies revealed a superficially invasive SCC with prominent papillary features and associated in situ carcinoma. The tumor cells were positive for p16 and were also positive for high-risk types of HPV using chromogenic in situ hybridization. The findings are consistent with a HPV-related SCC of the anal canal with papillary features. This tumor shows histologic features similar to a papillary HPV-related SCC of the oropharynx. Additional studies are needed to characterize these lesions.
人乳头瘤病毒（HPV）相关的累及肛管的鳞状细胞癌（SCC）是一种与高危型HPV相关的众所周知的癌症。具有乳头形态的HPV相关SCC（乳头状SCC）已在口咽中被描述。我们首次描述了一例具有乳头形态的肛门HPV相关鳞状癌病例。肿瘤起源于肛门黏膜。活检显示为浅表浸润性SCC，具有明显的乳头特征并伴有原位癌。肿瘤细胞p16阳性，使用显色原位杂交检测高危型HPV也呈阳性。这些发现与具有乳头特征的肛管HPV相关SCC一致。该肿瘤显示出与口咽乳头状HPV相关SCC相似的组织学特征。需要进一步研究来明确这些病变的特征。
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