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探索脊髓损伤管理的创新方法:对有前景的益生菌和后生元的综合综述

Exploring Innovative Approaches for Managing Spinal Cord Injury: A Comprehensive Review of Promising Probiotics and Postbiotics.

作者信息

Jamali Fereshteh, Mousavi Safa, Homayouni-Rad Aziz, Meshkini Ali, Alikhah Hossein, Houshyar Jalil, Kamalledin Moghadam Saba, Yaghoubi Seyyed Mohammad, Motlagh Asghari Kimia, Torbati Ilkhchi Masoud, Naseri Alavi Seyed Ahmad

机构信息

Neurosurgery Department, Children'S Hospital at Montefiore, New York City, USA.

Department of Public Health, College of Health and Human Services, California State University, Fresno, CA, USA.

出版信息

Probiotics Antimicrob Proteins. 2025 Apr 15. doi: 10.1007/s12602-025-10513-6.

Abstract

Spinal cord injury (SCI) affects millions of people worldwide annually, presenting significant challenges in functional recovery despite therapeutic advancements. Current treatment strategies predominantly focus on stabilizing the spinal cord and facilitating neural repair, yet their effectiveness remains uncertain and controversial. Recent scientific investigations have explored the potential of probiotics and postbiotics to modulate inflammation, influence neurotransmitters, and aid in tissue repair, marking a potential paradigm shift in SCI management. This review critically evaluates these innovative approaches, emphasizing their ability to harness the natural properties of microorganisms within the body to potentially enhance outcomes in SCI treatment. By analyzing the latest research findings, this review provides valuable insights into how probiotics and postbiotics can revolutionize inflammation management and neurological recovery following SCI, underscoring their promising role in future therapeutic strategies aimed at improving the quality of life of SCI patients globally.

摘要

脊髓损伤(SCI)每年影响着全球数百万人,尽管治疗取得了进展,但在功能恢复方面仍面临重大挑战。目前的治疗策略主要集中在稳定脊髓和促进神经修复,但其有效性仍不确定且存在争议。最近的科学研究探索了益生菌和后生元调节炎症、影响神经递质和辅助组织修复的潜力,这标志着脊髓损伤管理可能发生范式转变。本综述批判性地评估了这些创新方法,强调了它们利用体内微生物的天然特性来潜在改善脊髓损伤治疗结果的能力。通过分析最新研究结果,本综述提供了关于益生菌和后生元如何彻底改变脊髓损伤后的炎症管理和神经恢复的宝贵见解,强调了它们在旨在改善全球脊髓损伤患者生活质量的未来治疗策略中的有望作用。

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