肝脏培养系统中遗传毒性和表观遗传致癌物的鉴定
Identification of genotoxic and epigenetic carcinogens in liver culture systems.
作者信息
Williams G M
出版信息
Regul Toxicol Pharmacol. 1985 Jun;5(2):132-44. doi: 10.1016/0273-2300(85)90027-3.
PMID:4023285
Abstract
Liver culture systems are available for identifying the DNA reactivity of carcinogens and a cell membrane effect, which appears to be associated with neoplasm-promoting ability. Using these and other approaches, carcinogens can be categorized as genotoxic or epigenetic. This distinction has implications for risk assessment.
摘要
肝脏培养系统可用于识别致癌物的DNA反应性和一种细胞膜效应，这种效应似乎与肿瘤促进能力有关。利用这些方法及其他方法，致癌物可分为基因毒性或表观遗传毒性。这种区分对风险评估有影响。
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