Donovan Lois E, Bell Rhonda C, Yamamoto Jennifer M, Lemieux Patricia, Ho Josephine, Feig Denice S, Virtanen Heidi, Crawford Susan, Reimer Raylene A
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Diabetes Care. 2025 Aug 1;48(8):1337-1341. doi: 10.2337/dc25-0096.
To examine relationships between maternal glucose and breast milk composition and volume ingested by infants of mothers with type 1 diabetes (T1D), and to compare breast milk composition in women with and without T1D.
Midfeed breast milk samples were collected from 11 mothers with T1D. Maternal continuous glucose monitoring data were correlated with breast milk composition and volume ingested. Breast milk composition was compared between the women with T1D and five without T1D.
Forty-seven breast milk samples from mothers with T1D were analyzed. Maternal glucose 90-120 min before breastfeeding correlated with breast milk glucose and fructose but not with lactose, protein, fatty acids, leptin, or volume consumed. Breast milk leptin correlated with volume of breast milk consumed (r = 0.394; P = 0.008). Higher breast milk glucose (1.0 ± 0.3 vs. 0.7 ± 0.3 mg/mL) and leptin (463.6 ± 480.0 vs. 114.4 ± 68.6 pg/mL) were found in women with versus without T1D.
Maternal glucose is associated with breast milk glucose and fructose in women with T1D but not with volume of breast milk consumed.
研究1型糖尿病（T1D）母亲的血糖与母乳成分及婴儿摄入母乳量之间的关系，并比较患T1D和未患T1D女性的母乳成分。
收集了11名患T1D母亲的喂奶中期母乳样本。将母亲的持续血糖监测数据与母乳成分及摄入母乳量进行关联分析。比较了患T1D的女性和5名未患T1D女性的母乳成分。
分析了来自患T1D母亲的47份母乳样本。喂奶前90 - 120分钟的母亲血糖与母乳中的葡萄糖和果糖相关，但与乳糖、蛋白质、脂肪酸、瘦素或摄入母乳量无关。母乳中的瘦素与摄入母乳量相关（r = 0.394；P = 0.008）。患T1D的女性母乳中的葡萄糖（1.0 ± 0.3 vs. 0.7 ± 0.3毫克/毫升）和瘦素（463.6 ± 480.0 vs. 114.4 ± 68.6皮克/毫升）含量高于未患T1D的女性。
患T1D女性的母体血糖与母乳中的葡萄糖和果糖有关，但与母乳摄入量无关。
