Alimentómica SL, Palma de Mallorca, Spain.
Nutrigenomics and Obesity Group, Laboratory of Molecular Biology, Nutrition and Biotechnology, University of the Balearic Islands, Palma de Mallorca, Spain.
Nutr Rev. 2018 Dec 1;76(12):875-892. doi: 10.1093/nutrit/nuy046.
Leptin ingested as a component of breast milk is increasingly recognized to play a role in the postnatal programming of a healthy phenotype in adulthood. Besides its primary function in controlling body weight, leptin may be an essential nutrient required during lactation to ensure that the system controlling fat accumulation and body composition is well organized from the early stages of development. This review delves into the following topics: (1) the imprinted protective function of adequate leptin intake during lactation in future metabolic health; (2) the consequences of a lack of leptin intake or of alterations in leptin levels; and (3) the mechanisms described for the effects of leptin on postnatal programming. Furthermore, it highlights the importance of breastfeeding and the need to establish optimal or reference intake values for leptin during lactation to design patterns of personalized nutrition from early childhood.
母乳中摄入的瘦素在成年后对健康表型的产后编程中起着越来越重要的作用。除了其控制体重的主要功能外，瘦素可能是哺乳期所必需的重要营养物质，以确保从发育早期开始，控制脂肪积累和身体成分的系统得到很好的组织。这篇综述探讨了以下主题：（1）在未来的代谢健康中，哺乳期摄入足够的瘦素所具有的受印记保护的功能；（2）缺乏瘦素摄入或瘦素水平改变的后果；（3）描述瘦素对产后编程影响的机制。此外，它强调了母乳喂养的重要性，并需要在哺乳期确定瘦素的最佳或参考摄入量值，以便从儿童早期开始设计个性化营养模式。
