疟疾疫苗临床开发的最新观点。
Recent perspectives in clinical development of malaria vaccines.
作者信息
Feehan Jack, Plebanski Magdalena, Apostolopoulos Vasso
机构信息
School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
出版信息
Nat Commun. 2025 Apr 15;16(1):3565. doi: 10.1038/s41467-025-58963-4.
Abstract
Malaria vaccine research has progressed significantly, with RTS,S/AS01 and R21/Matrix-M receiving WHO endorsement in 2021 / 2023. These vaccines show promise, but challenges like vaccine adherence, strain variation, and resistance persist, highlighting the need for more effective, broad-reaching interventions.
摘要
疟疾疫苗研究取得了显著进展，RTS,S/AS01和R21/Matrix-M在2021年/2023年获得了世界卫生组织的认可。这些疫苗显示出了前景，但疫苗依从性、毒株变异和耐药性等挑战依然存在，这凸显了需要更有效、覆盖面更广的干预措施。
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