Liu Zhengqiong, Ke Shanbin, Wan Yuwen
College of Education, Jiangxi Institute of Applied Science and Technology, Nanchang, 330100, China.
Cancer Cell Int. 2025 Apr 15;25(1):145. doi: 10.1186/s12935-025-03784-0.
The microRNA miR-126 supports endothelial cells and blood vessel integrity. Recent research has shown that it also serves as a key link between exercise and cancer. This article delves into how exercise affects the expression of miR-126, impacting cardiovascular well-being and metabolic control. The article also examines the various contributions of miR-126 in cancer, acting as both a suppressor and an enhancer depending on the particular context. Regular aerobic exercises, including HIIT, consistently increase levels of miR-126, leading to enhanced angiogenesis, endothelial repair, and improved vascular function through mechanisms involving VEGF, HIF-1α, and EPC mobilization. Resistance training affects similar pathways, but does not cause a significant change in miR-126 levels.MiR-126 involves in cancer by suppressing tumor growth and controlling key pathways such as PI3K/Akt, ERK/MAPK, and EMT. Lower levels are associated with negative outcomes, later stages of the disease, and increased spread of different types of cancer like glioblastoma, CRC, ovarian, esophageal, gastric, and prostate cancer.The relationship between exercise and cancer suggests a possible therapeutic approach, where the regulation of miR-126 through exercise could help improve vascular function and slow tumor growth. Further studies should focus on understanding the specific molecular pathways through which miR-126 connects these areas, leading to potential interventions that utilize its regulatory network to promote cardiovascular well-being and enhance cancer treatment.
微小RNA miR - 126维持内皮细胞和血管完整性。近期研究表明，它也是运动与癌症之间的关键联系。本文深入探讨运动如何影响miR - 126的表达，进而影响心血管健康和代谢控制。文章还研究了miR - 126在癌症中的各种作用，根据具体情况，它既可以作为抑制因子，也可以作为增强因子。包括高强度间歇训练（HIIT）在内的常规有氧运动持续增加miR - 126水平，通过涉及血管内皮生长因子（VEGF）、低氧诱导因子 - 1α（HIF - 1α）和内皮祖细胞（EPC）动员的机制，导致血管生成增强、内皮修复改善和血管功能提升。抗阻训练影响类似途径，但不会使miR - 126水平发生显著变化。MiR - 126通过抑制肿瘤生长和控制关键信号通路如PI3K/Akt、ERK/MAPK和上皮 - 间质转化（EMT）参与癌症发生。较低水平与不良预后、疾病晚期以及不同类型癌症（如胶质母细胞瘤、结直肠癌、卵巢癌、食管癌、胃癌和前列腺癌）的扩散增加有关。运动与癌症之间的关系提示了一种可能的治疗方法，即通过运动调节miR - 126有助于改善血管功能和减缓肿瘤生长。进一步的研究应聚焦于了解miR - 126连接这些领域的具体分子途径，从而产生利用其调控网络促进心血管健康和增强癌症治疗效果的潜在干预措施。
