RNA 调控机制控制癌症中的 TGF-β 信号和 EMT。

RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer.

机构信息

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5000, Australia; School of Biological Sciences, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, SA 5000, Australia.

出版信息

Semin Cancer Biol. 2024 Jul;102-103:4-16. doi: 10.1016/j.semcancer.2024.06.001. Epub 2024 Jun 23.

DOI:10.1016/j.semcancer.2024.06.001

PMID:38917876

Abstract

Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are tightly controlled by non-coding RNAs - including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) - that collectively have major impacts on gene expression and resulting cellular states. While miRNAs are the best characterised regulators of EMT and TGF-β signaling and the miR-200-ZEB1/2 feedback loop plays a central role, important functions for lncRNAs and circRNAs are also now emerging. This review will summarise our current understanding of the roles of non-coding RNAs in EMT and TGF-β signaling with a focus on their functions in cancer progression.

摘要

上皮-间充质转化 (EMT) 是转移进展的主要贡献者，并且受到 TGF-β 信号的显著调节。EMT 和 TGF-β 途径成分都受到非编码 RNA 的严格控制，包括 microRNAs (miRNAs)、长非编码 RNA (lncRNAs) 和环状 RNA (circRNAs)，它们共同对基因表达和产生的细胞状态产生重大影响。虽然 miRNAs 是 EMT 和 TGF-β 信号的最佳特征调节剂，miR-200-ZEB1/2 反馈环起着核心作用，但 lncRNAs 和 circRNAs 的重要功能也正在出现。本文将总结我们目前对非编码 RNA 在 EMT 和 TGF-β 信号中的作用的认识，重点介绍它们在癌症进展中的功能。