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精准医学在直肠癌异时性肝转移预测中的应用与挑战

Precision medicine in the prediction of metachronous liver metastasis in rectal cancer: Applications and challenges.

作者信息

Ye Xu-Xing, Qu Hui-Heng, Yang Chao, Teng Wei-Jun, Chen Yan-Ping, Lin Jun-Mei, Wang Xiao-Bo

机构信息

Department of Traditional Chinese Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China.

Department of General Surgery, Wuxi No. 2 people's Hospital, Wuxi 214002, Jiangsu Province, China.

出版信息

World J Gastrointest Oncol. 2025 Apr 15;17(4):102469. doi: 10.4251/wjgo.v17.i4.102469.

DOI:10.4251/wjgo.v17.i4.102469
PMID:40235907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995326/
Abstract

Rectal cancer is a major global health concern, and metachronous liver metastasis (MLM) significantly worsens patient prognosis. Advances in imaging and machine learning have led to the development of radiomics models, particularly those utilizing multiparametric magnetic resonance imaging, which are highly valuable in predicting MLM. These models analyze imaging features to provide insights that can aid clinical decision-making and potentially improve treatment outcomes and survival rates. However, realizing the full potential of radiomics models faces challenges in terms of accuracy, generalizability, and data dependency. This editorial comments on a study regarding radiomics prediction models for rectal cancer MLM published recently in the , discusses the progress, challenges, and strategies for diagnostic models of MLM in rectal cancer, and proposes directions for future research.

摘要

直肠癌是一个重大的全球健康问题,异时性肝转移(MLM)会显著恶化患者预后。成像技术和机器学习的进展促使了影像组学模型的发展,特别是那些利用多参数磁共振成像的模型,这些模型在预测MLM方面具有很高的价值。这些模型分析成像特征以提供有助于临床决策的见解,并有可能改善治疗效果和生存率。然而,要充分发挥影像组学模型的潜力,在准确性、可推广性和数据依赖性方面面临挑战。这篇社论对最近发表在《》上的一项关于直肠癌MLM影像组学预测模型的研究进行了评论,讨论了直肠癌MLM诊断模型的进展、挑战和策略,并提出了未来研究的方向。

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本文引用的文献

1
Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis.基于多参数磁共振成像的影像组学模型预测直肠癌异时性肝转移
World J Gastrointest Oncol. 2025 Jan 15;17(1):96598. doi: 10.4251/wjgo.v17.i1.96598.
2
Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case report.帕博利珠单抗在错配修复缺陷转移性直肠癌中整合手术干预与观察等待方法:一例报告
Surg Case Rep. 2024 Aug 26;10(1):198. doi: 10.1186/s40792-024-01994-8.
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Significance of MRI-based radiomics in predicting pathological complete response to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: A narrative review.基于 MRI 的放射组学在预测局部晚期直肠癌新辅助放化疗病理完全缓解中的意义:叙述性综述。
Cancer Radiother. 2024 Aug;28(4):390-401. doi: 10.1016/j.canrad.2024.04.003. Epub 2024 Aug 22.
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Application of radiomics for preoperative prediction of lymph node metastasis in colorectal cancer: a systematic review and meta-analysis.基于放射组学的结直肠癌术前淋巴结转移预测的应用:系统评价和荟萃分析。
Int J Surg. 2024 Jun 1;110(6):3795-3813. doi: 10.1097/JS9.0000000000001239.
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Prediction by a multiparametric magnetic resonance imaging-based radiomics signature model of disease-free survival in patients with rectal cancer treated by surgery.基于多参数磁共振成像的影像组学特征模型对手术治疗的直肠癌患者无病生存期的预测
Front Oncol. 2024 Feb 22;14:1255438. doi: 10.3389/fonc.2024.1255438. eCollection 2024.
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The Role of Radiomics in Rectal Cancer.直肠癌的放射组学特征。
J Gastrointest Cancer. 2023 Dec;54(4):1158-1180. doi: 10.1007/s12029-022-00909-w. Epub 2023 May 8.
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Semin Cancer Biol. 2023 Jun;91:1-15. doi: 10.1016/j.semcancer.2023.02.006. Epub 2023 Feb 19.
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An MRI-based multi-objective radiomics model predicts lymph node status in patients with rectal cancer.基于 MRI 的多目标放射组学模型预测直肠癌患者的淋巴结状态。
Abdom Radiol (NY). 2021 May;46(5):1816-1824. doi: 10.1007/s00261-020-02863-2. Epub 2020 Nov 25.
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A radiomics-based model on non-contrast CT for predicting cirrhosis: make the most of image data.基于影像组学的非增强CT预测肝硬化模型:充分利用图像数据。
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