Pamanji Rajesh, Sivan Gisha
Department of Microbiology, Pondicherry University, R.V. Nagar, Kalapet, Puducherry 605014, India.
Division of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Chennai, TamilNadu 603203, India.
Toxicol Res (Camb). 2025 Apr 14;14(2):tfaf052. doi: 10.1093/toxres/tfaf052. eCollection 2025 Apr.
This opinion article questions the underlying causes of malformations observed in early developmental stages of zebrafish exposed to a range of chemicals. The research focuses on determining whether these developmental abnormalities arise due to the inherent sensitivity of zebrafish to chemical exposure or if they are related to the ubiquitous expression of certain genes within the zebrafish genome. By analysing different studies on zebrafish embryos to various chemical agents and analysing the resulting malformations, the study aims to differentiate between the effects of chemical sensitivity and the role of gene expression in developmental disruptions. Findings from this investigation will contribute to a deeper understanding of the mechanisms driving developmental toxicity in zebrafish, with implications for broader environmental and genetic research.
这篇观点文章对暴露于一系列化学物质中的斑马鱼早期发育阶段所观察到的畸形的潜在原因提出了质疑。该研究聚焦于确定这些发育异常是由于斑马鱼对化学物质暴露的固有敏感性所致，还是与斑马鱼基因组内某些基因的普遍表达有关。通过分析关于斑马鱼胚胎对各种化学制剂的不同研究，并分析由此产生的畸形，该研究旨在区分化学敏感性的影响与基因表达在发育破坏中的作用。这项调查的结果将有助于更深入地理解驱动斑马鱼发育毒性的机制，对更广泛的环境和基因研究具有启示意义。
