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基于阴阳理论阐释金匮肾气丸与明目地黄丸治疗糖尿病肾病的差异机制

Elucidating the Differential Mechanisms of Jingui Shenqi Pill and Mingmu Dihuang Pill in the Treatment of Diabetic Nephropathy Based on Yin-Yang Theory.

作者信息

Bi Shijie, Xu Zhenzhen, Yuan Anlei, Wang Zewen, Liu Yanxia, Yu Bin, Tian Jiaye, Liu Chaoqun, Qiao Liansheng, Wang Zhibin, Zhang Yanling

机构信息

Key Laboratory of TCM-information Engineer of State Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.

Beijing Tong Ren Tang Technology Development Co., Ltd, Beijing, 100000, People's Republic of China.

出版信息

Drug Des Devel Ther. 2025 Apr 10;19:2817-2831. doi: 10.2147/DDDT.S517143. eCollection 2025.

DOI:10.2147/DDDT.S517143
PMID:40236300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998986/
Abstract

BACKGROUND

The Yin-Yang attributes of MMDH and JGSQ in treating diabetic nephropathy (DN) remain unexplored.

METHODS

UPLC-MS identified formula components, network pharmacology analyzed common DN targets, and in vitro renal fibrosis models assessed efficacy. Transcriptomics revealed key pathways, and molecular docking simulated component-target interactions.

RESULTS

UPLC-MS confirmed the compositional complexity of MMDH and JGSQ. Network pharmacology indicated their involvement in multiple DN-related pathways. In vitro, JGSQ alleviated fibrosis and enhanced adhesion via FN and E-cad, while MMDH reduced interstitial fibrosis via FN and VIM. Transcriptomics showed JGSQ regulates the TGF-β pathway, and MMDH modulates the TNF pathway. Molecular docking confirmed key components binding to TGFB1 and TNFA.

CONCLUSION

MMDH and JGSQ exhibit distinct chemical compositions, targets, and pathways, underscoring their Yin-Yang regulatory roles in kidney function.

摘要

背景

目前尚未探究明目地黄丸（MMDH）和金匮肾气丸（JGSQ）治疗糖尿病肾病（DN）的阴阳属性。

方法

超高效液相色谱-质谱联用（UPLC-MS）鉴定方剂成分，网络药理学分析常见的DN靶点，体外肾纤维化模型评估疗效。转录组学揭示关键通路，分子对接模拟成分-靶点相互作用。

结果

UPLC-MS证实了MMDH和JGSQ的成分复杂性。网络药理学表明它们参与多种与DN相关的通路。在体外，JGSQ通过纤连蛋白（FN）和E-钙黏蛋白（E-cad）减轻纤维化并增强黏附，而MMDH通过FN和波形蛋白（VIM）减少间质纤维化。转录组学显示JGSQ调节转化生长因子-β（TGF-β）通路，而MMDH调节肿瘤坏死因子（TNF）通路。分子对接证实关键成分与转化生长因子β1（TGFB1）和肿瘤坏死因子α（TNFA）结合。

结论

MMDH和JGSQ表现出不同的化学成分、靶点和通路，突出了它们在肾功能中的阴阳调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd2/11998986/746f96de7989/DDDT-19-2817-g0010.jpg
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