Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study.

PURPOSE

This study aimed to explore the effect of preoperative different doses of esketamine on postoperative recovery in patients undergoing gynecologic laparoscopic surgery.

METHODS

A total of 99 women scheduled for gynecologic laparoscopic surgery under general anesthesia were enrolled and randomized. Three minutes before surgical incision, patients in the three groups were intravenously administered 0.25 mg/kg esketamine, 0.5 mg/kg esketamine, and an equivalent dose of saline, respectively. The primary outcome was the Quality of Recovery-15 (QoR-15) score assessed on 1 day (pod1), 3 days (pod3), and 7 days postoperatively (pod7). Secondary outcomes encompassed the VAS score, MAP, HR, frequency of rescue analgesia and length of hospital stay.

RESULTS

Compared with group C, QoR-15 score was significantly improved in group E and E on pod1, while the rest VAS score was significantly decreased at 6h postoperatively (19.164, < 0.001; = 6.059, = 0.034). On pod1, the VAS scores at rest and movement in group E were significantly lower than those in group C ( = 0.007, = 0.038). There was a significant decrease in resting VAS scores in the E group compared with group C on pod3 ( = 0.021). Compared with group C, the QoR-15 score in group E increased on pod7 ( = 0.008), but there was no clinical difference. There was no significant difference in MAP and HR among the three groups at each time point ( = 0.758, = 0.471; = 0.232, = 0.794). There was a significant difference in the number of postoperative rescue analgesia among the three groups ( = 0. 023).

CONCLUSION

Preoperative single small dose of esketamine can improve the quality of recovery 24h after gynecologic laparoscopic surgery patients, decrease the number of rescue analgesia, and may contribute to the rapid recovery of patients. And 0.5 mg/kg esketamine seems to be better.