Mortensen J, Djurhuus J C, Frøkiaer J, Tofft H P
Scand J Urol Nephrol. 1985;19(1):37-43. doi: 10.3109/00365598509180220.
The upper urinary tract of the pig was subjected to acute standardized obstructions, size 10-F, 8-F and 6-F, in both the proximal and the distal part of the ureter. Each obstruction was followed by measurements of the renal pelvic pressure-flow relationship between 0 and 20 ml/ureter/min. The study showed that the mean baseline pressure in the renal pelvis changed due to the obstruction with an increase related to the degree of obstruction. When the flow was increased a pressure-flow relationship in essence similar to the normal pressure-flow relationship was revealed. Thus phase 1, which is the pressure-flow relationship at low flow rate with urine flowing into a relaxed ureter, was practically eliminated and phase 2 was shifted to the left. The linear pressure-flow relationship in phase 3 was preserved but there was tendency for higher increments with increasing degree of obstruction. Even in cases of severe obstruction both baseline measurements and perfusion pressure measurements showed results well within the normal accepted limits of renal pelvic pressure. It was furthermore shown that the overlap was smallest at the low flow rates between 0 and 2 ml/ureter/min. All degrees of distal obstruction had a lower pressure at flow rates below 10 ml/ureter/min than proximal obstruction, a pressure difference which could be attributed to the peristaltic activity of the ureter.(ABSTRACT TRUNCATED AT 250 WORDS)
对猪的上尿路在输尿管近端和远端进行急性标准化梗阻，梗阻尺寸分别为10-F、8-F和6-F。每次梗阻后，测量肾盂压力与流量在0至20毫升/输尿管/分钟之间的关系。研究表明，肾盂的平均基线压力因梗阻而改变，且与梗阻程度相关而升高。当流量增加时，呈现出与正常压力-流量关系基本相似的压力-流量关系。因此，第一阶段，即低流量时尿液流入松弛输尿管的压力-流量关系实际上消失了，第二阶段向左偏移。第三阶段的线性压力-流量关系得以保留，但随着梗阻程度增加，压力升高趋势更明显。即使在严重梗阻的情况下，基线测量和灌注压力测量结果也都在肾盂压力正常可接受范围内。此外还表明，在0至2毫升/输尿管/分钟的低流量时重叠最小。在流量低于10毫升/输尿管/分钟时，所有程度的远端梗阻压力都低于近端梗阻，这种压力差可归因于输尿管的蠕动活动。（摘要截选至250字）
