Djurhuus J C, Constantinou C E
Urol Res. 1982;10(6):267-70. doi: 10.1007/BF00255872.
We present the results of a study designed to characterise urine transport in the healthy and chronically obstructed upper urinary tract. Fifteen healthy and 11 hydronephrotic pigs were used; experimental hydronephrosis was produced by partially obstructing the ureter. Data consisting of the peristaltic rate, bolus volume, and the urine flow rate were collected and related to varying increments of diuresis. The transmission characteristics of renal pelvic to ureteric contractions were studied by extracellular electrodes. Similarly, in hydronephrotic preparations we studied the transmission between the proximal and middle pelvis to the ureter. In healthy preparations, the contraction frequency of the renal pelvis and the ureter is identical, while in obstructive cases, the contraction frequency of the upper pelvis is not coordinated with the lower pelvis or ureter. While diuresis increased bolus volume to a maximum of 1,200% in the healthy and 660% in the hydronephrotic kidney, the peristaltic rate changed by only 45% and 50% respectively. The results of this study show that chronic ureteric obstruction alters the coordination of ureteric peristalsis and thereby disrupts the pacemaker mechanisms of the renal pelvis.
我们展示了一项旨在描述健康及慢性梗阻的上尿路中尿液输送情况的研究结果。使用了15只健康猪和11只肾积水猪；通过部分阻塞输尿管制造实验性肾积水。收集了包括蠕动频率、团注体积和尿流率的数据，并将其与不同程度的利尿增量相关联。通过细胞外电极研究肾盂至输尿管收缩的传导特性。同样，在肾积水标本中，我们研究了肾盂近端和中部至输尿管之间的传导。在健康标本中，肾盂和输尿管的收缩频率相同，而在梗阻病例中，上肾盂的收缩频率与下肾盂或输尿管不协调。虽然利尿使健康肾脏的团注体积最大增加1200%，肾积水肾脏增加660%，但蠕动频率分别仅改变45%和50%。本研究结果表明，慢性输尿管梗阻会改变输尿管蠕动的协调性，从而破坏肾盂的起搏机制。
