文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

6-芳基异吲哚啉-1-酮：新型代谢型谷氨酸受体2负变构调节剂

6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.

作者信息

Li Yinlong, Liang Steven H

机构信息

Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United State.

出版信息

ACS Med Chem Lett. 2025 Mar 26;16(4):512-513. doi: 10.1021/acsmedchemlett.5c00106. eCollection 2025 Apr 10.

DOI:10.1021/acsmedchemlett.5c00106
PMID:40236532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995207/
Abstract

This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR). Chemical synthesis and potency (IC) data for both mGluR and mGluR are disclosed.

摘要

本亮点介绍了作为代谢型谷氨酸受体2（mGluR）的负变构调节剂（NAMs）开发的新型6-芳基异吲哚啉-1-酮衍生物。文中披露了mGluR和mGluR的化学合成及效价（IC）数据。

相似文献

[1]
6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.

ACS Med Chem Lett. 2025-3-26

[2]
Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2.

ACS Med Chem Lett. 2025-3-19

[3]
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.

J Pharmacol Exp Ther. 2007-7

[4]
Discovery of 6,7-Dihydropyrazolo[1,5-]pyrazin-4(5)-one Derivatives as mGluR Negative Allosteric Modulators with Activity in a Rodent's Model of Cognition.

J Med Chem. 2024-9-12

[5]
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.

ACS Med Chem Lett. 2023-7-12

[6]
Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2.

ACS Pharmacol Transl Sci. 2024-7-10

[7]
Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.

J Med Chem. 2010-11-24

[8]
Brexanolone, zuranolone and related neurosteroid GABA receptor positive allosteric modulators for postnatal depression.

Cochrane Database Syst Rev. 2025-6-26

[9]
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.

Bioorg Med Chem Lett. 2020-5-1

[10]
Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia.

Expert Opin Ther Pat. 2009-9

本文引用的文献

[1]
Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2.

ACS Pharmacol Transl Sci. 2024-7-10

[2]
mGlu2/3 receptor antagonists for depression: overview of underlying mechanisms and clinical development.

Eur Arch Psychiatry Clin Neurosci. 2023-10

[3]
Are mGluR2/3 Inhibitors Potential Compounds for Novel Antidepressants?

Cell Mol Neurobiol. 2023-7

[4]
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases.

Pharmacol Ther. 2022-11

[5]
Challenges in the Discovery and Optimization of mGlu Heterodimer Positive Allosteric Modulators.

Lett Drug Des Discov. 2019-12

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索