6-芳基异吲哚啉-1-酮：新型代谢型谷氨酸受体2负变构调节剂
6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.
作者信息
Li Yinlong, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United State.
出版信息
ACS Med Chem Lett. 2025 Mar 26;16(4):512-513. doi: 10.1021/acsmedchemlett.5c00106. eCollection 2025 Apr 10.
Abstract
This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR). Chemical synthesis and potency (IC) data for both mGluR and mGluR are disclosed.
摘要
本亮点介绍了作为代谢型谷氨酸受体2（mGluR）的负变构调节剂（NAMs）开发的新型6-芳基异吲哚啉-1-酮衍生物。文中披露了mGluR和mGluR的化学合成及效价（IC）数据。
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