新型6-芳基异吲哚啉-1-酮衍生物作为代谢型谷氨酸受体2的负变构调节剂

Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2.

作者信息

Li Yinlong, Liang Steven H

机构信息

Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.

出版信息

ACS Med Chem Lett. 2025 Mar 19;16(4):510-511. doi: 10.1021/acsmedchemlett.5c00107. eCollection 2025 Apr 10.

DOI:10.1021/acsmedchemlett.5c00107

PMID:40236541

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995233/

Abstract

This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR). The chemical synthesis, selectivity over mGluR, and pharmaceutical compositions of those compounds are disclosed.

摘要

本亮点介绍了一系列新型6-芳基异吲哚啉-1-酮衍生物，作为代谢型谷氨酸受体2（mGluR）的负变构调节剂（NAMs）。公开了这些化合物的化学合成、对mGluR的选择性以及药物组合物。