新型6-芳基异吲哚啉-1-酮衍生物作为代谢型谷氨酸受体2的负变构调节剂
Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2.
作者信息
Li Yinlong, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 Mar 19;16(4):510-511. doi: 10.1021/acsmedchemlett.5c00107. eCollection 2025 Apr 10.
Abstract
This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR). The chemical synthesis, selectivity over mGluR, and pharmaceutical compositions of those compounds are disclosed.
摘要
本亮点介绍了一系列新型6-芳基异吲哚啉-1-酮衍生物，作为代谢型谷氨酸受体2（mGluR）的负变构调节剂（NAMs）。公开了这些化合物的化学合成、对mGluR的选择性以及药物组合物。
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