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作为用于治疗哮喘或慢性阻塞性肺疾病的NLRP3抑制剂的新型化合物。

Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2025 Apr 1;16(4):538-539. doi: 10.1021/acsmedchemlett.5c00143. eCollection 2025 Apr 10.

Abstract

Provided herein are novel compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma or COPD, and processes for preparing such compounds.

摘要

本文提供了作为NLRP3抑制剂的新型化合物、药物组合物、此类化合物在治疗哮喘或慢性阻塞性肺疾病中的用途以及制备此类化合物的方法。

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引用本文的文献

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Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD.
ACS Med Chem Lett. 2025 Apr 26;16(5):760-761. doi: 10.1021/acsmedchemlett.5c00218. eCollection 2025 May 8.

本文引用的文献

1
Epigenetic targets and their inhibitors in the treatment of idiopathic pulmonary fibrosis.
Eur J Med Chem. 2025 May 5;289:117463. doi: 10.1016/j.ejmech.2025.117463. Epub 2025 Mar 1.
2
Novel Triazine Derivatives as NLRP3 Inhibitors for Treating Asthma or COPD.
ACS Med Chem Lett. 2025 Jan 24;16(2):200-201. doi: 10.1021/acsmedchemlett.5c00020. eCollection 2025 Feb 13.
4
The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications.
Clin Exp Med. 2024 Sep 26;24(1):231. doi: 10.1007/s10238-024-01492-z.
5
Inflammasome components as new therapeutic targets in inflammatory disease.
Nat Rev Immunol. 2025 Jan;25(1):22-41. doi: 10.1038/s41577-024-01075-9. Epub 2024 Sep 9.

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