Li Kailang, Xie Fang, Xiong Yongfu, Jiang Jin, Huang Bifan
Department of Radiology, The Third People's Hospital In Xindu District of Chengdu, Chengdu, China.
Department of Oncology, The Second People's Hospital of Yibin, Yibin, China.
Front Immunol. 2025 Apr 1;16:1583228. doi: 10.3389/fimmu.2025.1583228. eCollection 2025.
Immunological tolerance and immune metabolism play crucial roles in maintaining immune homeostasis and the immune response to diseases. The advancement of molecular imaging technologies, particularly optical molecular imaging, nuclear medicine imaging, and magnetic resonance imaging, has led to a significant progress in the visualization of immune tolerance and immune metabolism. Molecular imaging technologies enable real-time monitoring and analysis of dynamic changes in immune tolerance mechanisms and immune metabolism in living organisms, allowing the development of new strategies for early disease diagnosis, targeted therapy, and immunotherapy. This article reviews the latest advancements in the application of molecular imaging technologies in the fields of immunological tolerance and immune metabolism, with a focus on their applications in the regulation of immune tolerance regulation, immune metabolism, and immunotherapy.
免疫耐受和免疫代谢在维持免疫稳态及对疾病的免疫反应中发挥着关键作用。分子成像技术的进步,尤其是光学分子成像、核医学成像和磁共振成像,已在免疫耐受和免疫代谢的可视化方面取得了显著进展。分子成像技术能够对活生物体中免疫耐受机制和免疫代谢的动态变化进行实时监测和分析,从而推动早期疾病诊断、靶向治疗和免疫治疗新策略的开发。本文综述了分子成像技术在免疫耐受和免疫代谢领域应用的最新进展,重点关注其在免疫耐受调节、免疫代谢及免疫治疗中的应用。