Seetharaman Jayendra, Poddar Ujjal, Srivastava Anshu, Sarma Moinak Sen, Yachha Surender Kumar
Department of Pediatric Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India.
JGH Open. 2025 Apr 15;9(4):e70162. doi: 10.1002/jgh3.70162. eCollection 2025 Apr.
BACKGROUND/AIMS: Pediatric functional abdominal pain disorders (FAPDs) subtypes; functional dyspepsia (FD), irritable bowel syndrome (IBS), functional abdominal pain-not otherwise specified (FAP-NOS), and abdominal migraine (AM) are influenced by demographic and social factors. The study aimed to evaluate the spectrum and demographic and social factors associated with FAPD subtypes.
Consecutive children (< 18 years) diagnosed with FAPD subtypes according to ROME-IV criteria between April 2018 and March 2020 were included. The clinical, demographic, and social parameters were analyzed between various subtypes of FAPD, and factors responsible for severe symptoms were studied.
A total of 479 children (mean age 12.34 ± 3.82 years, 60% boys) were included. FAP-NOS (63%) was the most commonly diagnosed subtype followed by IBS (17.4%) and FD (15%). The age at presentation, site of pain, duration of symptoms, and associated symptoms were significantly different among the three main subtypes ( < 0.001). Stressors could be identified in 39.3% and academic pressure (22.3%) was the most common. Family members with functional disorders (OR: 2.21, 95% CI: 1.31-3.42, = 0.02), presence of stressors (OR: 2.03, 95% CI: 1.14-3.65, = 0.016), and rural origin (OR: 1.75, 95% CI: 1.08-2.83, = 0.023) predicted severe symptoms.
FAP-NOS is the most common FAPD subtype in children in India. Children with FAP-NOS are much younger than other subtypes of FAPD. The presence of stressors and functional disorders in family members could be associated with severe symptoms. However, it mandates more prospective studies to validate the findings.
背景/目的:儿童功能性腹痛障碍(FAPDs)的亚型,即功能性消化不良(FD)、肠易激综合征(IBS)、未另行规定的功能性腹痛(FAP-NOS)和腹型偏头痛(AM),会受到人口统计学和社会因素的影响。本研究旨在评估与FAPD亚型相关的范围、人口统计学和社会因素。
纳入2018年4月至2020年3月期间根据罗马IV标准诊断为FAPD亚型的连续儿童(<18岁)。分析了FAPD各亚型之间的临床、人口统计学和社会参数,并研究了导致严重症状的因素。
共纳入479名儿童(平均年龄12.34±3.82岁,60%为男孩)。FAP-NOS(63%)是最常诊断出的亚型,其次是IBS(17.4%)和FD(15%)。三种主要亚型在发病年龄、疼痛部位、症状持续时间和相关症状方面存在显著差异(<0.001)。39.3%的儿童可识别出应激源,其中学业压力(22.3%)最为常见。有功能性疾病的家庭成员(比值比:2.21,95%置信区间:1.31-3.42,P=0.02)、存在应激源(比值比:2.03,95%置信区间:1.14-3.65,P=0.016)以及来自农村地区(比值比:1.75,95%置信区间:1.08-2.83,P=0.023)预示着会出现严重症状。
FAP-NOS是印度儿童中最常见的FAPD亚型。患有FAP-NOS的儿童比其他FAPD亚型的儿童年龄小得多。家庭成员中存在应激源和功能性疾病可能与严重症状有关。然而,这需要更多前瞻性研究来验证这些发现。