Hassell D, Utt J K
South Med J. 1985 Aug;78(8):1015-6. doi: 10.1097/00007611-198508000-00037.
The patient described had a markedly enhanced response to warfarin when he was given erythromycin concomitantly. Before the initiation of erythromycin, his warfarin anticoagulation had been well controlled. After withdrawal of erythromycin, his response to warfarin returned to normal. These findings and previously reported clinical and laboratory data lead to the conclusion that, at least in some patients, a potentially serious interaction between erythromycin and warfarin can occur.
所述患者在同时服用红霉素时，对华法林的反应明显增强。在开始使用红霉素之前，他的华法林抗凝效果一直控制良好。停用红霉素后，他对华法林的反应恢复正常。这些发现以及先前报道的临床和实验室数据得出结论：至少在一些患者中，红霉素和华法林之间可能会发生潜在的严重相互作用。
