Schwartz J, Bachmann K, Perrigo E
South Med J. 1983 Jan;76(1):91-3. doi: 10.1097/00007611-198301000-00026.
In the patient described, marked exacerbation of the hypoprothrombinemic response to warfarin coincided with the addition of erythromycin to the drug regimen. A subsequent study in rats provided evidence that erythromycin is capable of increasing the anticoagulant response to single doses of warfarin. On the basis of case findings, preliminary laboratory data, and related clinical data we conclude that the interaction between warfarin and erythromycin is one of potential significance.
在所描述的患者中，对华法林的低凝血酶原血症反应显著加剧与在药物治疗方案中添加红霉素同时发生。随后在大鼠身上进行的一项研究提供了证据，表明红霉素能够增强对单剂量华法林的抗凝反应。基于病例发现、初步实验室数据及相关临床数据，我们得出结论：华法林与红霉素之间的相互作用具有潜在的重要意义。
