Hicks N, Zack M, Caldwell G G, McKinley T W
South Med J. 1985 Aug;78(8):903-8. doi: 10.1097/00007611-198508000-00003.
For the period 1975 to 1980, melanoma incidence in persons 10 through 49 years of age in a southwest Georgia town was significantly increased compared with US rates (expected = 9; observed = 41) and Atlanta rates (expected = 13; observed = 41). We surveyed 36 white patients with melanoma and 74 unaffected control subjects to identify risk factors possibly associated with melanoma in this population. When compared with the controls, the patients more often had a history of melanoma in family members [odds ratio (OR) = 8.00; 95% confidence limits (CL) = 0.89 to 71.6; P = .063]; skin sensitivity to sun exposure (OR = 1.63; CL = 1.04 to 2.56; P = 0.016); or preexisting pigmented nevi (OR = infinity; one-sided 95% lower limit = 1.94, P = .005). More male patients had melanomas on covered body sites, though 67% of melanomas in both sexes occurred on normally covered sites. Patients in our study also had been exposed more often than controls to sick animals in the year before onset (OR = 3.18; CL = 0.92 to 11.0; P = .055) and to pesticides in nonoccupational settings (OR = 3.56; CL = 0.87 to 14.5; P = .059).
在1975年至1980年期间，佐治亚州西南部一个城镇10至49岁人群的黑色素瘤发病率与美国发病率（预期=9；观察到=41）和亚特兰大发病率（预期=13；观察到=41）相比显著升高。我们调查了36例黑色素瘤白人患者和74名未受影响的对照受试者，以确定该人群中可能与黑色素瘤相关的危险因素。与对照组相比，患者更常具有家族成员黑色素瘤病史[比值比（OR）=8.00；95%置信区间（CL）=0.89至71.6；P=0.063]；皮肤对阳光暴露敏感（OR=1.63；CL=1.04至2.56；P=0.016）；或既往存在色素痣（OR=无穷大；单侧95%下限=1.94，P=0.005）。更多男性患者的黑色素瘤发生在身体有遮盖的部位，尽管两性中67%的黑色素瘤发生在通常有遮盖的部位。我们研究中的患者在发病前一年比对照组更常接触患病动物（OR=3.18；CL=0.92至11.0；P=0.055）以及在非职业环境中接触杀虫剂（OR=3.56；CL=0.87至14.5；P=0.059）。
