Fujii Tomoko, Bando Hironori, Yamamoto Masaaki, Kanzawa Maki, Kanie Keitaro, Urai Shin, Tsujimoto Yasutaka, Sawabe Fumikazu, Fukazawa Keiko, Hanayama Asa, Yamada Tomoko, Yoshino Kei, Fukuoka Hidenori, Ogawa Wataru
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
J Endocrinol Invest. 2025 Apr 16. doi: 10.1007/s40618-025-02579-4.
Approximately 20% of pheochromocytomas are cystic in nature. However, research on the correlation between catecholamine and metanephrine fractions in cystic fluid and peripheral blood is limited. This study investigated the relationship between catecholamine fractions and their metabolites in peripheral blood and cystic fluid.
Five patients with pathologically diagnosed cystic pheochromocytomas were included in the analysis. Catecholamine fractions and their metabolites in the cystic fluid were measured. The relationship between phenylethanolamine N-methyltransferase (PNMT) expression in tumor tissues and catecholamine fractions of cystic fluid was also assessed.
The elevated patterns of catecholamine and metanephrine fractions in the cystic fluid were consistent with those observed in the peripheral blood of two patients. However, in two other patients. discordance was observed, with normetanephrine predominance in the peripheral blood despite adrenaline/metanephrine and noradrenaline/normetanephrine elevations in the cystic fluid. Immunohistochemical analysis revealed that PNMT expression in tumor tissues and the elevated pattern of catecholamine fractions in the peripheral blood were consistent in all patients, except for one patient with non-elevated peripheral blood catecholamines. However, in cystic fluid, the predominantly catecholamine fraction did not consistently align with PNMT expression.
In cystic pheochromocytoma, the elevation patterns of catecholamine fractions in cysts may not align with those in the peripheral blood and may differ relative to PNMT expression in tumor tissues.
约20%的嗜铬细胞瘤本质上是囊性的。然而，关于囊液和外周血中儿茶酚胺与甲氧基肾上腺素组分之间相关性的研究有限。本研究调查了外周血和囊液中儿茶酚胺组分与其代谢产物之间的关系。
分析纳入5例经病理诊断为囊性嗜铬细胞瘤的患者。测量囊液中的儿茶酚胺组分及其代谢产物。还评估了肿瘤组织中苯乙醇胺N-甲基转移酶（PNMT）表达与囊液儿茶酚胺组分之间的关系。
两名患者囊液中儿茶酚胺和甲氧基肾上腺素组分的升高模式与外周血中观察到的一致。然而，在另外两名患者中，观察到不一致情况，尽管囊液中肾上腺素/甲氧基肾上腺素及去甲肾上腺素/去甲氧基肾上腺素升高，但外周血中去甲氧基肾上腺素占主导。免疫组化分析显示，除一名外周血儿茶酚胺未升高的患者外，所有患者肿瘤组织中的PNMT表达与外周血中儿茶酚胺组分的升高模式一致。然而，在囊液中，主要的儿茶酚胺组分与PNMT表达并不始终一致。
在囊性嗜铬细胞瘤中，囊肿中儿茶酚胺组分的升高模式可能与外周血中的不一致，且可能与肿瘤组织中的PNMT表达有所不同。
