Sharma Surabhi, Das Jyoti, Subramanyam Deepa
National Centre for Cell Science, Pune, 411007, India; Regional Centre for Biotechnology, Faridabad, 121001, India.
National Centre for Cell Science, Pune, 411007, India; S P Pune University, Ganeshkhind, Pune, 411007, India.
Curr Opin Cell Biol. 2025 Jun;94:102518. doi: 10.1016/j.ceb.2025.102518. Epub 2025 Apr 15.
Intracellular trafficking is known to regulate the outcomes of cellular signalling, with its role in signal generation, reception and interpretation well appreciated. Trafficking within cells can control ligand release, generate and maintain morphogen gradients, regulate ligand uptake within a cell and integrate multiple signals that ultimately result in altered gene expression. This process is especially important over the course of development of multicellular organisms wherein signals within a developing embryo result in the generation of specialized cells. In this review, we discuss recent developments in our understanding of how intracellular trafficking modulates signalling output and ultimately, cellular identity and highlight recent findings that help us advance our understanding of how the cross talk between trafficking and cell signalling dictates cell fate.
已知细胞内运输可调节细胞信号传导的结果，其在信号产生、接收和解读中的作用已得到充分认识。细胞内的运输可以控制配体释放、产生并维持形态发生素梯度、调节细胞内的配体摄取以及整合多种信号，最终导致基因表达改变。这一过程在多细胞生物的发育过程中尤为重要，其中发育胚胎内的信号会导致特化细胞的产生。在本综述中，我们讨论了在理解细胞内运输如何调节信号输出以及最终细胞身份方面的最新进展，并强调了一些最新发现，这些发现有助于我们进一步理解运输与细胞信号传导之间的相互作用如何决定细胞命运。
