Nedaeinia Reza, Dianat-Moghadam Hassan, Movahednasab Maedeh, Khosroabadi Zahra, Keshavarz Mohsen, Amoozgar Zohreh, Salehi Rasoul
Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Int Immunopharmacol. 2025 May 16;155:114597. doi: 10.1016/j.intimp.2025.114597. Epub 2025 Apr 15.
Ferroptosis is a regulated cell death process that results in decreased tumor growth and aggressiveness when targeted in various cancer cells. Studying the impact of ferroptosis in glioblastoma (GBM) will provide important knowledge about tumor biology and potential treatment strategies. The high metabolic activity resulting in ROS production, iron content and active lipid metabolism of glioblastoma cells make them particularly susceptible to ferroptosis. Single-cell RNA sequencing reveals the molecular signature of GBM and its tumor microenvironment, introducing ferroptosis-related biomarkers pathways and drug resistance mechanisms to enhance treatment outcomes for GBM patients. The relationship between ferroptosis and the immune landscape in GBM is complex and can have either positive or negative effects. These effects can be identified through single-cell RNA sequencing to develop targeted chemo-, radio- and immuno- therapies against glioma stem cells and tumor-supportive immune cells. Additionally, the implication of oncolytic virotherapy in combination with ferroptosis induction can lead to improved treatment of GBM in a clinical setting.
铁死亡是一种受调控的细胞死亡过程，当针对各种癌细胞时，会导致肿瘤生长和侵袭性降低。研究铁死亡在胶质母细胞瘤（GBM）中的影响将为肿瘤生物学和潜在治疗策略提供重要知识。胶质母细胞瘤细胞的高代谢活性导致活性氧产生、铁含量增加和活跃的脂质代谢，使其特别容易发生铁死亡。单细胞RNA测序揭示了GBM及其肿瘤微环境的分子特征，引入了铁死亡相关的生物标志物途径和耐药机制，以提高GBM患者的治疗效果。铁死亡与GBM免疫格局之间的关系很复杂，可能产生正面或负面影响。这些影响可以通过单细胞RNA测序来确定，以开发针对胶质瘤干细胞和肿瘤支持性免疫细胞的靶向化疗、放疗和免疫疗法。此外，溶瘤病毒疗法与诱导铁死亡相结合可能会在临床环境中改善GBM的治疗。
